Small-molecule Methoxy Linear PEG (mPEG)
| Cat. No. | Product Name | CAS No. | |
|---|---|---|---|
| BPG-2690 | mPEG48-propionic acid | Inquiry | |
| BPG-2691 | mPEG48-CH2CH2COONHS ester | Inquiry | |
| BPG-3577 | mPEG10-bromide | Inquiry | |
| BPG-4699 | m-PEG8-t-butyl ester | 2768015-32-1 | Inquiry |
| BPG-4700 | m-PEG9-t-butyl ester | 2768015-30-9 | Inquiry |
| BPG-4701 | m-PEG10-t-butyl ester | 2768015-31-0 | Inquiry |
| BPG-4702 | m-PEG12-t-butyl ester | Inquiry | |
| BPG-4703 | m-PEG13-t-butyl ester | Inquiry | |
| BPG-4705 | m-PEG23-alcohol | 2640205-23-6 | Inquiry |
| BPG-4706 | m-PEG4-(CH2)3-alcohol | 145526-76-7 | Inquiry |
| BPG-4707 | m-PEG8-propargyl | 2730134-74-2 | Inquiry |
| BPG-4708 | m-PEG11-Ms | 502487-25-4 | Inquiry |
| BPG-4709 | m-PEG8-BBTA | Inquiry | |
| BPG-4710 | Mal-PEG4-Lys(TFA)-NH-m-PEG24 | 2384191-64-2 | Inquiry |
| BPG-4711 | NH2-PEG4-Lys(t-Boc)-NH-m-PEG24 | Inquiry | |
| BPG-4712 | N-Boc-N'-(mPEG24)-L-Lysine-OH | 2353409-83-1 | Inquiry |
| BPG-4713 | N-Boc-Methoxy-tris(ethylenoxy)-L-alanin | Inquiry | |
| BPG-4714 | m-PEG7-(CH2)3-alcohol | 1807512-35-1 | Inquiry |
| BPG-4715 | m-PEG3-t-butyl ester | 1778219-81-0 | Inquiry |
| BPG-4716 | mPEG12-SPDP | Inquiry |
Small-molecule methoxy linear PEG (mPEG) is a polymer with a PEG chain with reactive groups at one end and a methoxy group at the other. It typically has a lower molecular weight and offers greater reactivity and modification flexibility. Small-molecule methoxy linear PEG (mPEG) has excellent solubility, biocompatibility, long cyclic half-life and modifiability, making it a promising candidate for a wide range of applications in drug delivery, nanomedicine, materials science, and biomedical research, etc.
BOC Sciences provides customers with high-purity, high-quality and homogeneous small-molecule methoxy linear PEG (mPEG) products. This type of polymer can be combined with various functional groups such as carboxyl, amino, azide, hydrazide, etc., which gives small-molecule methoxy linear PEG (mPEG) a wealth of functionalities.
Structural Features of Small-molecule Methoxy Linear PEG (mPEG)
- Linear structure - mPEG is a linear polymer with high flexibility and plasticity.
- Degree of polymerization - mPEG consists of glycol units (-OCH2CH2-) repeatedly linked, and the degree of polymerization can be adjusted as needed. The higher the degree of polymerization, the higher the molecular weight of the mPEG, and its physical and chemical properties will vary.
- Methoxy groups - Methoxy groups give mPEG good water solubility and biocompatibility, while also helping to modify its chemical reactivity and interactions.
- End groups - The end groups of mPEG can be chemically modified, which can adjust the properties and functions of mPEG.
Preparation of Small-molecule Methoxy Linear PEG (mPEG)
Pretreatment Experiments
The methoxy glycol is reacted with an amount of base to remove impurities and acidic components from it.
Preparation of Activator
Appropriate activators such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) are selected for promoting the reaction between methoxyglycol and polyethylene glycol monomers.
Polymerization Reaction
The activator is added to the pretreated methoxyethylene glycol and the polyethylene glycol monomer (e.g., ethylene glycol) is added for the reaction. The reaction time and temperature are determined based on the specific reaction conditions and the desired molecular weight of the mPEG.
Purification and Extraction
The resulting reaction mixture needs to be purified and extracted to remove unreacted substances, by-products and other impurities.
Advantages of Small-molecule Methoxy Linear PEG (mPEG)
- Permeability
Small-molecule methoxy linear PEG (mPEG) has a relatively small molecular weight, which can penetrate biological barriers more easily and has a permeation enhancement effect, which can improve the efficiency and effectiveness of drug delivery. - Reduce Drug Immunogenicity
Small-molecule methoxy linear PEG (mPEG) reduces the interaction between the drug and the immune system by binding to the surface of the drug molecule, thus reducing the immunogenicity of the drug. - Controlled Release Properties
By adjusting the covalent binding or physical adsorption of small-molecule methoxy linear PEG (mPEG) to the drug, precise control of the rate and pattern of drug release can be achieved. This is important for the design and optimization of drug-controlled release systems to achieve sustained drug release and reduced drug dose frequency.
BOC Sciences offers mPEG derivatives with various functional groups such as amines (NH2), thiols (SH), azides (N3), NHS esters, maleimides (Mal), and more. You can find the ideal small-molecule methoxy linear PEG (mPEG) for the development of your project. If you don't find the product you need in our online catalog, contact us and we can provide you with a custom synthesis of the product.
Why BOC Sciences？
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- What are Biotinylation and Biotinylated PEG?
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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