Custom Synthesis PEG Derivatives
BOC Sciences provides many types of activated PEGs with wide variety of functional groups, whereby can be further introduced into drugs, enzymes, peptide, proteins, nanoparticles and other biologics, playing important roles in the augmentation the targeting ability, stabilization of conjugates, reduction of their antigenicity and/or decrease in the drug doses.
PEG, as obtained by ethylene oxide polymerization, presents one or two terminal hydroxyl groups (mPEG-OH or HO-PEG-OH) depending upon the initiator of polymerization: methanol or water, respectively. Because the repeating ethylene oxide units of PEG possess no reactive side moieties, PEG is bound to other compounds through terminal functional groups to realize activation.
Below are the application of PEG Derivatives
Fig. 1 Versatility of PEG modification. (Expert opinion on drug delivery, 2009, 6(1): 1-16)
How to Modify?
Two approaches are commonly used:
- Alteration of the terminal hydroxyl group through a series of reactions to a more active functional group
- Through reaction of PEG under controlled conditions with difunctional compounds so that one of the functional groups reacts with PEG and the other remains active.
*In most cases, several steps are conducted to achieve the expected derivatization.
PEG Derivatives We Can Offer Including but Not Limited to:
The mono-functional linear PEGs contain highly purified methoxy groups, which can effectively prevent the occurrence of bridging reactions (side reactions) that hinder PEGylation. | |
Bifunctional PEG is the most popular starting point for cross-linking reaction between proteins, enzymes and other small molecule drugs. Moreover, it can also be utilized to prepare hydrogels for tissue engineering. | |
Forked PEGs provide multi-proximal reactive groups at one or both ends of a linear PEG chain. It can be applied in biobetters’ design attached to Fab’ antibody fragments to produce a conjugate similar in structure to the full-length antibody. | |
Multi-arm PEGs can be used not only as the starting materials for hydrogels, but also are indicated to enhance the loading of low molecule drugs. | |
Y-shaped PEG is more effective in protecting the conjugated protein from degradative enzymes and antibodies. Moreover, enzymes modified with this PEG retain more activity with those counterparts modified by linear PEGs. | |
These derivatives present two different functional groups, one for each extreme, which simplify the linking of different molecules to the same PEG chain. | |
This kind of PEG derivative has pH-cleavable acetyl linkers, which can be recognized and cleaved by lysosomal enzymes when the conjugates reach the intracellular compartment. | |
Monodisperse PEG is a pure compound with unique, specific and single molecular weight. Inserting monodisperse PEGs into small molecule drugs can well increase the hydrodynamic volume and solubility of the drugs, reduce aggregation and immunogenicity, as well as extend the half-life of drugs in the body. |
Why Us?
How to Order?
References
- Bailon P, Won C Y. PEG-modified biopharmaceuticals. Expert opinion on drug delivery, 2009, 6(1): 1-16.
- Santos, J. H. P. M.; Torres-Obreque, K. M.; et al. Protein PEGylation for the design of biobetters: from reaction to purification processes. Brazilian Journal of Pharmaceutical Sciences 2018, 54 (SPE).
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Lipid Classification and Drug Delivery Systems
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- What are Biotinylation and Biotinylated PEG?
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are Phospholipids?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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