DSPE, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)], is often utilized in drug delivery systems and as stabilizers for different medications and biotechnologies. It is a phospholipid derivative made up of two chains of stearic acid, a phosphoethanolamine head group, and the glycerol backbone. Polyethylene glycol (PEG) chains are added to the molecule to enhance solubility, stability, and biocompatibility. To improve the characteristics of liposomes and other lipid-based nanoparticles and enable targeted drug administration, DSPE PEG is frequently added to them.


DSPE PEG 2000 consists of a DSPE backbone that provides stability and structure and PEG chains that help improve the pharmacokinetics and biodistribution of encapsulated drugs. The capacity to increase the drug's circulation time in the body is one of the key benefits of employing DSPE PEG 2000. The PEG chains on the nanoparticles' surface create a barrier that lessens immune system detection and clearance. As a result, there is a higher likelihood that the medicine will reach the target location successfully since the nanoparticles may stay in the circulation for extended periods of time. Moreover, it has been demonstrated that DSPE PEG 2000 enhances medication biodistribution. The PEG chains aid in preventing toxicity-causing nanoparticle buildup in organs including the liver and spleen. Instead, tumor tissue is where nanoparticles are most likely to gather, where they can release medications from their encapsulation and have therapeutic effects. The therapeutic effectiveness of medications that are encapsulated can be improved by DSPE PEG 2000 in addition to pharmacokinetics and biodistribution improvements. Drug distribution that is prolonged and targeted can be achieved with the use of lipid-based nanoparticles, which can shield medications from deterioration and offer a regulated release mechanism.

DSPE PEG 2000 based lipid nanoparticlesFig. 1. DSPE PEG 2000 based lipid nanoparticles (Journal of Drug Delivery Science & Technology. 2016, 125-135).

DSPE PEG Maleimide

DSPE PEG maleimide is a lipid molecule commonly used in bioconjugation and drug delivery applications. It consists of DSPE and DSPE PEG maleimide is often employed in bioconjugation and drug delivery applications. It is made up of PEG chains connecting DSPE and maleimide groups. Selective conjugation of thiol-containing compounds, such as cysteine residues in proteins or thiolated polymers, is made possible by the maleimide group in DSPE PEG maleimide. As a result, it can be used as a tool to bind other biomolecules, medications, or imaging agents to liposomes or other lipid-based nanoparticles. The PEG chains in DSPE PEG maleimide provide a number of benefits, including better blood circulation time, decreased immunogenicity, and higher stability. Moreover, the hydrophilic PEG chains contribute to the biocompatibility and suppression of unfavorable immunological responses by preventing the aggregation and opsonization of lipid nanoparticles.


The surface characteristics of nanoparticles can be changed by adding PEG to DSPE amines to create DSPE PEG amine conjugates. This conjugation can speed up the circulation of nanoparticles in the body, improve immune system clearance of them, and increase their stability in biological fluids. Furthermore, the ability to functionalize DSPE PEG amines with targeting ligands and therapeutic molecules provides a versatile platform for targeted drug delivery. By attaching ligands that specifically recognize receptors on target cells, nanoparticles can be directed to specific tissues or cell types, thereby improving the selectivity and efficiency of drug delivery.


Biotin, also known as vitamin B7, is a small molecule with a high affinity for the avidin or streptavidin protein. Liposomes or nanoparticles may be selectively targeted and attached to biotin-binding proteins by adding DSPE PEG biotin into them. Common biological uses for this characteristic include targeted medication administration, imaging, and diagnostics. Amphiphilic substances like DSPE PEG Biotin have both hydrophilic and hydrophobic areas. This characteristic makes it possible for the creation of liposomes, lipoproteins, and other lipid-based delivery systems. It also facilitates self-assembly into lipid bilayers or micelles. In addition, DSPE biotin is more stable and soluble after PEGylation, has better pharmacokinetic characteristics, lower immunogenicity, and longer circulation time in the body.

Application of DSPE PEG

DSPE PEG is a versatile material with applications in a variety of fields, including drug delivery, imaging, diagnostics, and gene therapy. Its unique properties make it an attractive option for enhancing the performance and efficacy of therapeutic agents and diagnostic tools.

  • Liposomal drug delivery. DSPE PEG is commonly used as a component of liposomal drug delivery systems. It helps stabilize and prolong the circulation time of liposomes in the blood, thereby improving drug delivery to target tissues or organs. The PEG chains on DSPE PEG provide a hydrophilic surface that minimizes opsonization and prevents rapid clearance by the immune system.
  • Protein and peptide conjugation. DSPE PEG can be used for conjugation of proteins and peptides to liposomes or other nanoparticles. This conjugation can enhance the stability, solubility, and bioavailability of a therapeutic protein or peptide, as well as improve its targeting and controlled release properties.
  • Surface modification of nanoparticles. DSPE PEG can be used to modify the surface properties of various nanoparticles, such as gold nanoparticles or quantum dots. The PEG chains on DSPE PEG form a steric barrier that prevents nonspecific interactions with biological components, reducing immunogenicity and improving biocompatibility.
  • Imaging agents. DSPE PEG can be used to incorporate imaging agents such as fluorescent dyes or contrast agents into liposomes or other nanoparticles. This enables the visualization and tracking of nanoparticles in biological systems, facilitating the development of diagnostic imaging techniques.
  • Vaccine Delivery. DSPE PEG can be used to formulate liposomal or nanoparticle vaccines. Incorporation of antigens into these delivery systems can enhance their immunogenicity and improve immune responses. The PEG chains on DSPE PEG also help prevent aggregation and improve stability during storage and transportation.
  • Gene Delivery. DSPE PEG can be used to develop gene delivery systems such as lipoplex or polyplex. The PEG chains on DSPE PEG can increase the stability and biocompatibility of these systems and increase their cellular uptake and transfection efficiency.

BOC Sciences has extensive capabilities in supplying DSPE PEG to meet the diverse needs of customers. We have been committed to adopting strict quality control measures to ensure the purity, stability and consistency of DSPE PEG products. We can provide customers with comprehensive technical support in the selection, use and application of DSPE PEG. Our experienced team of scientists and experts are available to assist customers with any queries or technical challenges they may have.


  1. Vijayakumar, M.R. et al. Trans resveratrol loaded DSPE PEG 2000 coated liposomes: An evidence for prolonged systemic circulation and passive brain targeting. Journal of Drug Delivery Science & Technology. 2016, 125-135.

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