PEG & Click Chemistry Solutions

BOC Sciences is a leading supplier of PEG & click chemistry solutions for pharmaceuticals, biotechnology, and academic research. Our team of highly skilled chemists utilizes advanced techniques and state-of-the-art equipment to provide customized PEG functionalization and click chemistry solutions to meet your specific needs. We strictly adhere to cGMP guidelines and regulations to ensure the highest quality and safety of our products.

What is Click Chemistry?

Click chemistry is a set of chemical reactions that are highly efficient, modular, and selective. These reactions are typically used for the synthesis of complex molecules and drug conjugates. Click chemistry reactions are characterized by their high yield, fast reaction rate, and compatibility with a wide range of functional groups. The most commonly used click chemistry reactions include copper-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), and thiol-ene click reactions. These reactions have been widely used in drug discovery and development, bioconjugation, and materials science.

Schematic of click chemistry.Fig. 1. Schematic of click chemistry.

Application of PEG in Click Chemistry

In click chemical operations, PEGylation is frequently employed to improve the solubility, stability, and bioavailability of medicines and other compounds. Specifically, PEG is covalently joined to an interest molecule during PEGylation. PEGylation can improve the pharmacokinetics and pharmacodynamics of drugs by reducing their immunogenicity and clearance rate. PEGylation can also improve the effectiveness of click chemistry processes by increasing the solubility and stability of the reactants. Moreover, PEGylation can increase the bioactivity of drug conjugates made by click chemistry by decreasing non-specific binding and lengthening their stay in circulation.

Our PEG & Click Chemistry Technologies

BOC Sciences can provides click chemistry solutions for the synthesis of complex molecules and drug conjugates. Our PEGylation services can improve drug solubility, stability, and half-life, as well as reduce immunogenicity and toxicity. We also offer a variety of PEGylation linkers to ensure optimal conjugation efficiency and bioactivity.

Schematic of click chemistry.

Copper-catalyzed Azide-alkyne Cycloaddition (CuAAC)

Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is one of the most widely used click chemistry reactions. CuAAC is the process by which a triazole ring is formed when an azide and an alkyne react with a copper catalyst. This reaction can be carried out under simple reaction conditions and is very efficient and selective. CuAAC is an effective tool for click and PEGylation chemistry. It allows for the efficient and selective conjugation of molecules, resulting in improved solubility, stability, and bioactivity. BOC Sciences offers a wide range of CuAAC services for PEGylation and click chemistry, as well as custom synthesis of PEGylated molecules and drug conjugates.

Strain-promoted Alkyne-azide Cycloaddition (SPAAC)

Strain-promoted alkyne-azide cycloaddition (SPAAC) is a type of click chemistry reaction that involves the reaction of an alkyne and an azide group in the absence of a copper catalyst. SPAAC is a highly efficient and selective reaction that can be performed under mild reaction conditions, making it ideal for PEGylation and click chemistry applications. Among the several SPAAC services offered by BOC Sciences are PEGylation, click chemistry, bespoke PEGylated molecule synthesis, and drug conjugates.

Thiol-ene Click Reactions

Thiol-ene click reactions are a type of click chemistry reaction that involves the reaction of a thiol group and an alkene group in the presence of a photoinitiator. One of the main applications of thiol-ene click reactions in PEGylation and click chemistry is the conjugation of PEG to a molecule of interest. This involves the functionalization of the molecule with a thiol or alkene group, followed by the reaction with a PEG derivative containing the complementary functional group. BOC Sciences supplies a wide range of thiol-ene click reaction solutions for PEG & click chemistry to facilitate the application of PEG in drug development and medical diagnostics.

Our cGMP Manufacturing Capabilities of PEGs

BOC Sciences has extensive cGMP manufacturing capabilities in the field of PEG and PEGylation. We have a dedicated team of scientists, engineers, and quality control personnel who specialize in the development, synthesis, and production of PEGylated molecules and drug conjugates. We offer a wide range of PEGylation services, including:

Schematic of click chemistry.

At BOC Sciences, we are committed to providing high-quality PEG & click chemistry solutions at competitive prices. We use only the highest quality reagents and follow strict quality control procedures to ensure consistency and reproducibility. Contact us today to learn more about our PEG & click chemistry solutions and how we can help advance your research and development projects.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



Our Feature

BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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