PEG & Click Chemistry Solutions

BOC Sciences is a leading supplier of PEG & click chemistry solutions for pharmaceuticals, biotechnology, and academic research. Our team of highly skilled chemists utilizes advanced techniques and state-of-the-art equipment to provide customized PEG functionalization and click chemistry solutions to meet your specific needs. We strictly adhere to cGMP guidelines and regulations to ensure the highest quality and safety of our products.

What is Click Chemistry?

Click chemistry is a set of chemical reactions that are highly efficient, modular, and selective. These reactions are typically used for the synthesis of complex molecules and drug conjugates. Click chemistry reactions are characterized by their high yield, fast reaction rate, and compatibility with a wide range of functional groups. The most commonly used click chemistry reactions include copper-catalyzed azide-alkyne cycloaddition (CuAAC), strain-promoted alkyne-azide cycloaddition (SPAAC), and thiol-ene click reactions. These reactions have been widely used in drug discovery and development, bioconjugation, and materials science.

Fig. 1. Schematic of click chemistry.

Application of PEG in Click Chemistry

In click chemical operations, PEGylation is frequently employed to improve the solubility, stability, and bioavailability of medicines and other compounds. Specifically, PEG is covalently joined to an interest molecule during PEGylation. PEGylation can improve the pharmacokinetics and pharmacodynamics of drugs by reducing their immunogenicity and clearance rate. PEGylation can also improve the effectiveness of click chemistry processes by increasing the solubility and stability of the reactants. Moreover, PEGylation can increase the bioactivity of drug conjugates made by click chemistry by decreasing non-specific binding and lengthening their stay in circulation.

Our PEG & Click Chemistry Technologies

BOC Sciences can provides click chemistry solutions for the synthesis of complex molecules and drug conjugates. Our PEGylation services can improve drug solubility, stability, and half-life, as well as reduce immunogenicity and toxicity. We also offer a variety of PEGylation linkers to ensure optimal conjugation efficiency and bioactivity.

Our cGMP Manufacturing Capabilities of PEGs

BOC Sciences has extensive cGMP manufacturing capabilities in the field of PEG and PEGylation. We have a dedicated team of scientists, engineers, and quality control personnel who specialize in the development, synthesis, and production of PEGylated molecules and drug conjugates. We offer a wide range of PEGylation services, including:

• Custom synthesis of PEG derivatives of various molecular weights and functional groups.
• Conjugation of PEG to biomolecules, drugs, peptides and proteins.
• Development and scale-up of PEGylation processes for large-scale production.
• Analytical testing and quality control of PEGylated products, including purity, identity, and stability testing.
• cGMP manufacturing of PEGylated products for clinical trials and commercialization.

At BOC Sciences, we are committed to providing high-quality PEG & click chemistry solutions at competitive prices. We use only the highest quality reagents and follow strict quality control procedures to ensure consistency and reproducibility. Contact us today to learn more about our PEG & click chemistry solutions and how we can help advance your research and development projects.