Small-molecule Methoxy Linear PEG (mPEG)

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Small-molecule methoxy linear PEG (mPEG) is a polymer with a PEG chain with reactive groups at one end and a methoxy group at the other. It typically has a lower molecular weight and offers greater reactivity and modification flexibility. Small-molecule methoxy linear PEG (mPEG) has excellent solubility, biocompatibility, long cyclic half-life and modifiability, making it a promising candidate for a wide range of applications in drug delivery, nanomedicine, materials science, and biomedical research, etc.

BOC Sciences provides customers with high-purity, high-quality and homogeneous small-molecule methoxy linear PEG (mPEG) products. This type of polymer can be combined with various functional groups such as carboxyl, amino, azide, hydrazide, etc., which gives small-molecule methoxy linear PEG (mPEG) a wealth of functionalities.

Structural Features of Small-molecule Methoxy Linear PEG (mPEG)

  • Linear structure - mPEG is a linear polymer with high flexibility and plasticity.
  • Degree of polymerization - mPEG consists of glycol units (-OCH2CH2-) repeatedly linked, and the degree of polymerization can be adjusted as needed. The higher the degree of polymerization, the higher the molecular weight of the mPEG, and its physical and chemical properties will vary.
  • Methoxy groups - Methoxy groups give mPEG good water solubility and biocompatibility, while also helping to modify its chemical reactivity and interactions.
  • End groups - The end groups of mPEG can be chemically modified, which can adjust the properties and functions of mPEG.

Preparation of Small-molecule Methoxy Linear PEG (mPEG)


Pretreatment Experiments

The methoxy glycol is reacted with an amount of base to remove impurities and acidic components from it.

Preparation of Activator

Appropriate activators such as dicyclohexylcarbodiimide (DCC) or 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) are selected for promoting the reaction between methoxyglycol and polyethylene glycol monomers.

Polymerization Reaction

The activator is added to the pretreated methoxyethylene glycol and the polyethylene glycol monomer (e.g., ethylene glycol) is added for the reaction. The reaction time and temperature are determined based on the specific reaction conditions and the desired molecular weight of the mPEG.

Purification and Extraction

The resulting reaction mixture needs to be purified and extracted to remove unreacted substances, by-products and other impurities.

Advantages of Small-molecule Methoxy Linear PEG (mPEG)

  • Permeability
    Small-molecule methoxy linear PEG (mPEG) has a relatively small molecular weight, which can penetrate biological barriers more easily and has a permeation enhancement effect, which can improve the efficiency and effectiveness of drug delivery.
  • Reduce Drug Immunogenicity
    Small-molecule methoxy linear PEG (mPEG) reduces the interaction between the drug and the immune system by binding to the surface of the drug molecule, thus reducing the immunogenicity of the drug.
  • Controlled Release Properties
    By adjusting the covalent binding or physical adsorption of small-molecule methoxy linear PEG (mPEG) to the drug, precise control of the rate and pattern of drug release can be achieved. This is important for the design and optimization of drug-controlled release systems to achieve sustained drug release and reduced drug dose frequency.

BOC Sciences offers mPEG derivatives with various functional groups such as amines (NH2), thiols (SH), azides (N3), NHS esters, maleimides (Mal), and more. You can find the ideal small-molecule methoxy linear PEG (mPEG) for the development of your project. If you don't find the product you need in our online catalog, contact us and we can provide you with a custom synthesis of the product.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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