PEG & Drug Delivery Solutions

With the development of drugs from small molecules to peptides and proteins, to nucleic acid drugs, and finally to living cell therapy, new progress has been made in drug delivery technology. The challenges of various therapies can be well resolved through drug modification and microenvironment regulation. Emerging PEG-based drug delivery systems are the pharmaceutical industry's gold standard for treating diseases such as cancer, hemophilia, pain or diabetes. BOC Sciences has developed a one-stop service platform for drug delivery to support the activation and conjugation of PEG. Depending on the type of PEG-conjugated substrate, we can choose the reactive functional groups for PEG activation to achieve the desired drug delivery efficiency.

Fig. 1. Structure of PEG and its application in drug delivery (Journal of Controlled Release. 2020, 323: 565-577).

What Are the Applications of PEG in Drug Delivery?

Drug delivery technologies can enhance drug target delivery, minimize drug off-target effects and improve patient compliance. As therapeutics evolve from small molecules to nucleic acids, peptides, proteins, and antibodies, drug delivery technologies are also developing to address the new challenges. As a multifunctional conjugation ligand for drugs and drug delivery systems, PEG has been widely used as a solubilizing excipient in drug delivery system formulations. For example, PEGylation proteins can reduce the immunogenicity of proteins and prolong their half-life. PEGylated carbohydrates can be used as materials and carriers for new drugs. PEGylated oligonucleotides can improve solubility, nuclease resistance, and cell membrane permeability. PEGylated biomaterials can reduce thrombus formation and protein and cell adhesion.

Our PEG Solutions for Drug Delivery

At BOC Sciences, our researchers can help you achieve greater success in drug delivery by providing solutions for PEG synthesis, activation, modification and conjugation. Our expert scientists will pay close attention to your needs and provide you with comprehensive support before, during and after your experiments.

• Small molecule drug delivery solutions
• Protein drug delivery solutions
• Peptide drug delivery solutions
• Antibody drug delivery solutions
• Nucleic acid drug delivery solutions
• Nanocarrier drug delivery solutions
• Lipid drug delivery solutions
• Carbohydrate drug delivery solutions

Our PEG Manufacturing Capabilities

• Functionalized PEG synthesis and development
• PEG-drug conjugation strategy development
• Analytical validation and screening of pegylated drugs
• Development of PEGylated drug delivery system
• In vitro ADME detection of pegylated drugs
• In vivo & in vitro pharmacology analysis of pegylated drugs
• Pharmacokinetic testing of pegylated drugs
• cGMP manufacturing of PEGylated drugs

Advantages of PEG in Drug Delivery

• Maintaining the spatial configuration and biological activity of drug molecules
• Promoting the targeting of drug molecules to lesion tissues or target cells
• Enhancing the efficiency of drug molecules across all levels of biological barriers
• Improving the efficiency of intracellular drug delivery and release

Our PEG Solution Service Workflow

BOC Sciences has created successful PEG-based drug delivery support services for many customers. We have in-depth knowledge and experience of the tools and processes involved in the development of PEG and PEGylated drugs. We have many years of experience in drug delivery development process design, system selection, implementation and support. Whether your organization is in the discovery and screening phase or planning for PEGylated drug synthesis, please contact us to learn how we can help you to ensure your next success.