PEG Crosslinking Services
Polyethylene glycol derivatives with active functional groups are widely used as the gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. Conjugation of PEG to proteins and peptides, oligonucleotides (DNA, small interfering RNA (siRNA), micro RNA (miRNA)), and nanoparticles is a well-established technique. Over the years, BOC Sciences has been committed to providing cross-linking services between various modified PEGs and biomolecules. Our experienced technicians can select the most suitable linker according to the type of biomolecule and PEG molecule to optimize the solubility, immunogenicity and biological functionality of the drug.
What is PEG Crosslinking?
The cross-linking reaction of PEG generally includes PEG, coupled drugs and/or linkers and other components. In the application of PEG, the end group plays a decisive role. PEGs with different end groups serve different purposes. Since the terminal group of PEG raw material is a hydroxyl group, which has the disadvantages of low biological activity, difficulty in stably combining with drugs, and narrow modification range. Therefore, in practical applications, other more reactive functional groups, such as amino groups, carboxyl groups, and aldehyde groups, are often introduced into the end groups to synthesize PEG derivatives. These functionalized groups are rich in chemical activity, for example, they can be combined with specific amino acids, and then can be cross-linked with various biomolecules and small molecule drugs.
Fig. 1. Schematic representation of the PEG crosslinking reaction.
BOC Sciences has launched a variety of popular PEG derivatives by using various conjugation strategies with key parameters of PEG structure and molecular weight (MW) to achieve good efficacy of PEG-conjugated drugs. We can select PEG compounds with branched chain structures, such as branched chain PEG, forked PEG and multi-arm PEG, etc., achieving multiple cross-linking possibilities and greatly increasing the drug loading capacity. Our PEG crosslinking strategy has been widely used in biomedical applications such as drug delivery, biosensing, imaging, and tissue engineering.
Advantages of PEG Crosslinked Molecules
- Improving pharmacodynamic properties
- Reducing known toxicities
- Improving drug stability
- Improving in vivo drug distribution
- Improving pharmacokinetic properties
- Improving solubility
Our PEG Crosslinking Capabilities
BOC Sciences has developed a systematic crosslinking strategy for crosslinking PEGylated antibodies, peptides, proteins, siRNA, oligonucleotides, carbohydrates, nanoparticles, biotin and small molecule drugs. Our PEG derivatives include amine, thiol, carboxyl and carbonyl modified PEG molecules. Additionally, our conjugation linkers include acid cleavable, enzymatically cleavable, and non-cleavable linkers.
Our PEG Crosslinking Feature Services
Crosslinking Antibody to Nanoparticles | Crosslinking Proteins to Nanoparticles |
Crosslinking Antibody to Small Molecules | Crosslinking Proteins to Small Molecules |
Crosslinking Antibody to Carbohydrates | Crosslinking Proteins to Carbohydrates |
Crosslinking Antibody to siRNA | Crosslinking Proteins to siRNA |
Crosslinking Antibody to Oligonucleotide | Crosslinking Proteins to Oligonucleotide |
Crosslinking Peptides to Nanoparticles | Crosslinking siRNA to Nanoparticles |
Crosslinking Peptide to Small Molecules | Crosslinking siRNA to Small Molecules |
Crosslinking Peptide to Carbohydrates | Crosslinking siRNA to Carbohydrates |
Crosslinking Peptide to siRNA | Crosslinking siRNA to Oligonucleotide |
Crosslinking Peptide to Oligonucleotide | Crosslinking Oligonucleotide to Nanoparticles |
Crosslinking Biotin to Carbohydrates | Crosslinking Oligonucleotide to Small Molecules |
Crosslinking Biotin to Small Molecules | Crosslinking Oligonucleotide to Carbohydrates |
Quality Assurance
We develop and manufacture a wide range of PEG derivatives with high purity and low polydispersity under our ISO 9001 and ISO 13485 certified quality management system. At the same time, we also follow the ICH Q7A guidelines and operate according to the cGMP protocol. If you are interested in our PEG crosslinking service, please contact us for more information.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- Multi-Arm PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Services
- PEGylation Services
- PEGylation Analysis and Method Verification
- Surface Modification and Functionalization
- PEGylated Biodegradable Polymers Synthesis
- Monodisperse PEG Synthesis
- Custom Synthesis PEG Derivatives
- PEG cGMP Manufacture
- PEG Crosslinking Services
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
- Industry News
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS

PEG linkers For Drug
Improved Circulation Half-Life
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