Olefin/Alkene/Vinyl PEG

Background

Olefin/Alkene/Vinyl PEG can be synthesized by a variety of methods, the most common of which involves the introduction of olefinic functional groups, such as vinyl, propenyl, or other olefinic groups, onto the PEG molecule. These olefinic groups can be reacted with other compounds with olefinic groups to functionalize and modify the PEG.

Fig. 1. Alkene PEG as a linker (Angewandte Chemie International Edition. 2021, 60(49): 25856-25864).

Examples of Olefin/Alkene/Vinyl PEGs

Olefin PEG

Olefin-PEG introduces an olefinic functional group, such as a vinyl or propylene group, at the end of the PEG chain. The introduction of an olefinic functional group into olefin-PEG gives it the ability to react chemically with other compounds. By reacting with compounds having reactive functional groups, such as reactive vulcanizing agents, reactive esterifying agents, or reactive chlorinating agents, it is possible to link olefin-PEG to these compounds to form PEG derivatives with specific functions.

Alkene-PEG-Alkene

The specific properties and applications of alkene-PEG molecules depend on their molecular weight, the type and density of olefinic functional groups, and other possible modifications. By adjusting these parameters, modulation of the solubility, biocompatibility, stability and reactivity of alkene-PEG molecules can be achieved.

Vinyl PEG

The vinyl-PEG molecule is characterized by the introduction of a vinyl ether functional group at the end of the PEG chain. It can be polymerized by polymerization reactions (e.g., free radical polymerization) to form vinyl PEG-based polymers or copolymers. Properties such as biocompatibility, resistance to protein adsorption, and modulation of surface properties (e.g., hydrophilicity) can be provided by grafting vinyl-PEG onto the substrate surface.

Preparation of Olefin/Alkene/Vinyl PEGs

Terminal Functionalization of PEG

Protective groups (e.g., acyl or phosphate groups) are introduced at the end of PEG and then reacted with olefinic compounds, finally removing the protective groups.

Internal Functionalization of PEG

This method introduces olefinic functional groups within the PEG chain so that they are distributed in the middle of the PEG molecule. Using a suitable initiator and reaction conditions, olefinic monomers are introduced during the synthesis of PEG to polymerize with ethylene glycol monomers, resulting in the formation of PEGs with olefinic functional groups. The hydroxyl groups within the PEG chain are protected, and then reacted with olefinic compounds, with the final removal of the protecting groups.

End-group Modification of PEG

Other functional groups, such as carboxylic acid, aldehyde or amine groups, are introduced at the end of the PEG, and then olefinic functional groups are introduced to the other functional groups using appropriate reaction conditions. PEG is crosslinked with other molecules, such as polymers or small molecule compounds, using appropriate crosslinkers to form PEG crosslinking networks with olefins functional groups.

Areas of Surface Modification by Olefin/Alkene/Vinyl PEG

Surface Modification of Biosensors

Grafting Vinyl PEG onto the surface of biosensors can inhibit non-specific protein adsorption and cell adhesion, improving the selectivity and sensitivity of the sensors.

Medical Device Coatings

Modification of medical device surfaces with Olefin/Alkene/Vinyl PEG reduces platelet aggregation and thrombosis, prevents infection and promotes tissue repair.

Cell Culture Media Surface Modification

Introducing an Olefin/Alkene/Vinyl PEG modified layer on the surface of cell culture media can inhibit the adsorption of collagen and cells, and improve the efficiency of cell culture and cell survival. Biochip surface modification: modifying the surface of biochips with Olefin/Alkene/Vinyl PEG reduces non-specific protein adsorption and cell adhesion, and improves the sensitivity and specificity of the chip. This is important for molecular detection and high-throughput screening on biochips.

Nanoparticle and nanomaterial surface modification

By introducing Vinyl PEG modification on the surface of nanoparticles or nanomaterials, their dispersion, stability and biocompatibility can be enhanced. This is useful for applications such as drug delivery, bioimaging and biosensing.

As a trusted supplier of Olefin/Alkene/Vinyl PEG, BOC Sciences is committed to providing high-quality products to meet the evolving needs of researchers and industry professionals. If you have a need for our products, please feel free to contact us.

Reference

1. Macdougall, L. J. et al. Using Stereochemistry to Control Mechanical Properties in Thiol-Yne Click-Hydrogels. Angewandte Chemie International Edition. 2021, 60(49): 25856-25864.

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