Pre-mixed Lipid Blends

BOC Sciences offers our customers a wide range of pre-mixed lipid blends products, you can find the product for your project development in our list. Pre-mixed lipid blends, a concoction of diverse lipid types like phospholipids, cholesterol, and other lipids, are meticulously combined into a homogeneous mixture. The intricate composition of the lipid blend can be finely tuned to manipulate the characteristics of the resultant liposomes, including their size, stability, and release kinetics. For instance, augmenting the cholesterol content in the lipid blend has the potential to bolster the stability of liposomes and curtail their permeability. Furthermore, the formulation of pre-mixed lipid blends takes into account an array of nutritional requisites and therapeutic considerations, adding a layer of complexity and adaptability to the process.

Examples of Lipid Mixtures

Medium-chain Triglyceride (MCT) Blend

MCT blend is enriched with medium-chain triglycerides, which are typically composed of fatty acids with shorter carbon chain lengths. MCT is more readily utilized during digestion and absorption, and therefore provides a high energy source for patients with impaired intestinal function or those who are unable to digest long-chain fats.

Omega-3 Fatty Acid Blend

Omega-3 fatty acid blend is rich in omega-3 fatty acids such as EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). Omega-3 fatty acid blend is commonly used in the support of cardiovascular health, management of inflammatory diseases, and regulation of fat metabolism.

Soy Phospholipid Mixture

Soy lecithin is a mixed phospholipid composed of phosphatidylcholine, phosphatidylethanolamine, phosphatidyl inositol, phosphatidylserine and other ingredients. Soy lecithin can be used as a bioactive food additive and can also exhibit a variety of biochemical and physical effects to help prevent pathogenesis.

Benefits of Pre-mixed Lipid Blends

Good stability. Pre-mixed lipid blends can be stabilized in neutral pH buffer for several weeks after preparation into liposomes, which is suitable for continuous repetition of experiments.

Convenience. Pre-mixed lipid blends do not need to be formulated from scratch, reducing the time and effort required for formulation and mixing.

Precise lipid ratio. Pre-mixed lipid blends allow for precise lipid dosing based on specific needs and goals. This precise dosing ensures that patients receive the proper lipid intake to meet their nutritional needs.

Prepare Liposomes from Mixed Lipids

In the process of preparing liposomes from mixed lipid components, it is of paramount importance to ensure that the lipids are first and foremost solubilized and thoroughly mixed in an organic solvent to achieve a homogenous lipid mixture. Once the lipids have been adequately mixed in the organic solvent, the solvent is then removed to create a lipid film, which is a crucial step in the formation of liposomes. However, the method of solvent removal is dependent on the volume of the organic solvent used in the process. For organic solvents that are relatively small in volume (less than 1mL), the solvent can be evaporated in a fume hood using a dry nitrogen or argon stream. Conversely, for larger volumes of organic solvent, the organic solvent should be removed by rotary evaporation, which entails the formation of a lipid film on the inner wall of the round bottom flask.

Applications of Pre-mixed Lipid Blends

Premixed lipid mixtures play a crucial role in the realm of drug discovery, serving as indispensable tools for formulating liposomal drug delivery systems. By leveraging premixed lipid mixtures, researchers can swiftly concoct liposomal drug delivery systems, effectively slashing the time and costs typically entailed in the development of novel drug formulations. Furthermore, the consistent nature of premixed lipid mixtures fosters the uniformity of liposomal drug delivery systems, thereby enabling dependable and precise assessment of drug efficacy and safety. In the domain of nutritional supplement development, premixed lipid mixtures emerge as a potent source of high-energy-dense lipids that boast exceptional digestibility and absorbability, catering to the energy and nutritional requirements of patients. Notably, in the context of fat metabolism disorders induced by specific diseases or conditions, such as bile acid metabolism disorders and cholesterol metabolism disorders, premixed lipid mixtures can be meticulously customized to align with the patient's unique condition, fine-tuning lipid composition and fatty acid ratios to optimize fat metabolism equilibrium.

By premixing different types of lipid ingredients, BOC Sciences can fulfill specific nutritional needs or therapeutic goals. If you are interested in our lipid formulations, please get in touch with us.