PEGylation Services

PEGylation is a chemical process to couple polyethylene glycol (PEG) polymer chains to macromolecules, such as proteins, drugs or vesicles. By increasing the volume of drug molecules, it can effectively extend its half-life in the body, while shielding its immune sites to significantly reduce immunogenicity. PEGylation is one of the most effective long-acting protein preparation technology recognized internationally. As a leading biotechnology services supplier, BOC Sciences has advanced skills that can offer customized synthesis pathways of various PEGylated conjugates, such as peptides/proteins, oligonucleotides, small molecule drugs, as well as different types of nanocarriers for customers to meet their unique requirements.

What is PEGylation?

The PEGylation process involves covalently linking PEG molecules to drugs or therapeutic proteins through chemical conjugation. PEG is a hydrophilic, biocompatible, and nontoxic polymer that has been extensively studied and approved by regulatory agencies for drug delivery applications. By attaching PEG molecules to drug molecules, researchers can change their properties, such as increasing their solubility, stability and half-life in the body.

PEGylation Services and Reagents

One of the key advantages of PEGylation technology is the ability to prolong the circulation time of drugs in the body. PEG molecules form a protective barrier around drug molecules, preventing them from being quickly cleared by the immune system or enzymatically degraded. The extended circulation time allows the drug to reach its target tissue more efficiently and exert its therapeutic effect over a longer period of time. Additionally, PEGylation can reduce the immunogenicity of certain drugs by protecting them from recognition by the immune system. Examples include therapeutic proteins and antibodies, which may induce immune responses in some patients. By pegylating these drugs, researchers can minimize their immunogenic potential and improve their safety and tolerability in patients. By attaching PEG molecules to drug delivery systems such as liposomes or nanoparticles, researchers can extend their circulation time in the body, increase their tissue permeability, and increase their accumulation at specific target sites.

Tools for PEGylation

At BOC Sciences, we offer a variety of PEGylation reagents to help researchers and organizations improve the performance of their products. Our PEGylation services come in a variety of formats, including off-the-shelf reagents, custom PEGylation and manufacturing services. Our PEGylation reagents are designed to be multifunctional, efficient and easy to use, including PEG chains of different lengths and chemical linkers that can modify various molecules quickly and effectively. For researchers with more specialized needs, we also offer custom PEGylation services, where our team of experts can design and optimize PEGylation strategies based on their specific molecules.

PEGylation Services

In order to accomplish PEGylation, a variety of chemical modifications are utilized to prepare an active PEG derivative with a reactive functional group at one or both termini. Further the use of reactive functional group mainly depends on the substrate to be conjugated to PEG. Our PEGylation techniques can be roughly divided into the following parts:

PEGylation of Peptides and Proteins

Among the 20 types of common amino acids that make up proteins, only those with polar side chain groups can be chemically modified. The activated PEG realizes the coupling through chemical reaction with the amino acid residues on the peptide or protein molecules. The active groups on these amino acid residues are mostly nucleophilic, and their activity usually decreases in the following order: sulfhydryl > α-amino > ɛ-amino > carboxy > hydroxyl. With our expertise as a leader in the field of PEGylation, BOC Sciences can offer you great services to help you design desired PEGylated proteins

PEGylation of Nanocarriers

The addition of PEG to the nanocarrier surface can reduce many of challenges, such as reducing reticuloendothelial system (RES) uptake and increasing circulation time versus uncoated counterparts. Due to difference in the chemical make-up, strategies used for PEGylation of nanocarriers can be broadly classified under the titles of polymeric nanoparticles, liposomes, micelles and inorganic nanoparticles. Our expertise in polymer chemistry and surface science can provide you practice advices, help you design the experiment, and prepare PEG functionalized products for your needs.

PEGylation of Small Molecule Drugs

To date, many organic small molecule drugs have gradually adopted PEGylation technology and certain progress has been made. The conjugated drugs also has good biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly excreted from the body without any toxic side effects. Pease contact us for more details of our preclinical PEGylation service. BOC Sciences's dedicated and experienced PEGylation group will offer you the most optimal solution for your project.

PEGylation of Amino Acids

PEGylation of amino acids involves attaching PEG to the side chains of amino acids, which can improve the pharmacokinetic properties of biomolecules. PEGylation of amino acids can also reduce immunogenicity and increase the circulating half-life of peptides and proteins. BOC Sciences offers custom PEGylation services of amino acids with precise control over the degree of PEGylation and the size of the attached PEG chain.

PEGylation of Lipids

PEGylation of lipids is an effective strategy to improve the pharmacokinetic properties of lipid drugs. By attaching PEG chains to lipids, researchers can enhance the solubility, stability, and circulation time of lipid drug formulations, thereby improving bioavailability and therapeutic efficacy. Additionally, PEGylation can help reduce the immunogenicity and toxicity of lipid drugs, making them safer to use in patients. BOC Sciences can provide PEGylation services for a variety of lipid molecules, including phospholipids, cholesterol, and glycolipids.

PEGylation of Nucleic Acids

PEGylation of nucleic acids can improve their stability, pharmacokinetics, and biodistribution, as well as reduce immunogenicity and improve their cellular uptake, making them more suitable for therapeutic applications. BOC Sciences offers a wide range of nucleic acid PEGylation services, including PEGylation of RNA, DNA, siRNA, oligonucleotides, and other nucleic acid derivatives. We can perform PEGylation at various locations on nucleic acid molecules, including the 5' and 3' ends, internal sites, and specific functional groups.

PEGylation of Antibodies

PEGylation of antibodies is a widely used strategy to improve the pharmacokinetic properties and stability of therapeutic antibodies. BOC Sciences offers PEGylated antibodies and antibody fragment services, providing customized solutions to improve antibody stability, half-life and efficacy. We offer comprehensive services including PEGylation optimization, conjugation chemistry, analytical method development and quality control.

PEGylation of Carbohydrates

Carbohydrates are important biomolecules that play key roles in many biological processes and have multiple potential applications in the development of new drugs and therapies. PEGylation of carbohydrates can improve the pharmacokinetic properties and solubility of carbohydrate-based drugs and diagnostics. BOC Sciences can provide PEGylation services for a variety of carbohydrate molecules, including monosaccharides, oligosaccharides, and polysaccharides.

PEGylation of Biotin

Biotin is a vitamin, also known as vitamin H, that is an important component of biotechnology and biomedical research. PEGylation of biotin involves conjugating PEG chains to biotin molecules and can be achieved using PEGs of different molecular weights and structures. BOC Sciences can provide customized biotin PEGylation services based on customer specific requirements.

PEGylation of Enzymes

PEGylation of enzymes is a practical approach to improve the stability, solubility, and pharmacokinetic properties of enzyme-based therapeutics and diagnostics. BOC Sciences offers custom PEGylation services for enzymes, allowing for the attachment of PEG chains to enzyme molecules. PEGylation of enzymes can enhance their stability under harsh conditions, increase their solubility, and extend their circulating half-life. We can provide PEGylation services for a variety of enzymes, including proteases, lipases, and polymerases.

PEGylation of Cytokines

Cytokines are signaling proteins that regulate immune responses in the body, and when PEGylated, they can have longer half-lives and reduced toxicity, leading to more effective treatments. BOC Sciences offers PEGylation services for a variety of cytokines, including interleukins, interferons, and growth factors. Our PEGylation services are performed in state-of-the-art facilities using strict quality control measures to ensure the highest standards of product quality and consistency.

PEGylation Service Model

PEGylation Service Model 1

PEGylated Conjugates

PEGylation Service Model 2

One-stop PEGylation

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PEGylation Service Process

PEGylation Process


  1. Harris, J.M. et al. Effect of PEGylation on pharmaceuticals. Nature reviews Drug discovery. 2003, 2(3): 214-221.
  2. Kolate, A. et al. PEG-a versatile conjugating ligand for drugs and drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society. 2014, 192: 67-81.
  3. Pasut, G. et al. State of the art in PEGylation: the great versatility achieved after forty years of research. Journal of controlled release : official journal of the Controlled Release Society. 2012, 161(2): 461-72.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

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  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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