Group Protected PEG
Group protected PEG molecules have functional groups at the end of the chain protected by a protecting group. These protectors include Boc, Fmoc and small molecules. For example, the amine group in Fmoc-NH-PEG-SCM is protected by an Fmoc group. Upon reaction, the Fmoc protecting group is removed and the two reactive end groups can be reacted with different drug molecules to form a PEG linking the two drug molecules. The protected amine can be regenerated under weakly alkaline conditions. BOC Sciences provides PEG molecules linked by protecting groups that strategically protect certain functional groups, enabling selective conjugation and incorporation of customized groups to protect the properties of the PEG for specific applications.
Fig. 1. PEG synthesis using protecting group (Tetrahedron, 2022, 119: 132861).
How to Prepare Protected PEG?
Step 1 - Selection of Protective Reagents
Depending on the application, it is necessary to select suitable protective reagents that are chemically compatible with the desired reaction and are stable.
Step 2 - PEG Protecting Groupylation
Temporary protective groups are introduced by reacting the protective reagent with the target functional group in the PEG molecule. The combination of the two can be carried out by chemical reactions such as esterification, acylation, etc. The specific reaction conditions need to be optimized according to the protective reagent used as well as the moiety.
Step 3 - Reaction Monitoring and Purification
The progress of the chemical reaction and the reaction conditions can be monitored using NMR or mass spectrometry to ensure that the protective reagent has reacted with the PEG molecule. At the end of the reaction, purification techniques need to be used to remove incompletely reacted reagents, intermediate products, etc.
Step 4 - Exposure of Functional Groups
Exposure of the functional groups needs to be realized according to the chemical form of the specific group, which can generally be treated with acidic, alkaline and other conditions.
Applications of Group Protected PEG
Drug Delivery
In drug delivery, moiety-protected PEGs can be used to enhance the stability, solubility and biodistribution of therapeutic agents. By selectively removing temporary shielding groups, the exposed functional groups in the protected PEG can be affixed to drug molecules, targeting ligands, or other components, enabling the development of targeted drug delivery systems.
Surface Modification
When applied to surfaces such as biosensors, protected PEGs can enhance stability, minimize non-specific interactions, and provide controlled release properties. Selective removal of temporary shielding groups allows for precise attachment of functional groups to the surface, resulting in customized surface properties and specific interactions with biological systems.
Bioconjugation and Protein Engineering
By selectively exposing functional groups, protected PEGs can be conjugated to proteins or peptides to improve their stability, solubility and resistance to protein hydrolysis.
Advantages of Group Protected PEG
- Expertise and experience: We have a team of highly skilled experts in the synthesis and modification of PEG-based compounds.
- High quality and purity: Our Group Protected PEG undergoes stringent quality control measures and employs advanced analytical techniques to verify compound integrity and purity, providing customers with reliable and consistent products.
- Wide range of applications: Whether for drug delivery, surface modification or bioconjugation, our Group Protected PEG products can be tailored to meet the specific needs of different applications.
With expertise and a commitment to quality, BOC Sciences is a trusted partner in providing researchers and industry professionals with high-quality protected PEG compounds. If you are interested in our products, please do not hesitate to contact us at any time.
Reference
- Eriyagama, D.N.A.M. et al. Automated stepwise PEG synthesis using a base-labile protecting group. Tetrahedron. 2022, 119: 132861.
Why BOC Sciences?
-
Large Stock
More than 2000+ products in inventory
-
Global Delivery
Warehouses in multiple cities to ensure fast delivery
-
mg to kg
Multi specification for academic research and industrial production
-
24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
-
PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
-
PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
-
Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
-
Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
Learn More
APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
Learn More
Have Customer Reviewed On Us?
Chat With Us