Hydrazide PEG

What is Hydrazide PEG?

Hydrazide PEG linkers contain a hydrazide functional group that can be easily affixed to drugs, peptides and proteins. This functional group is highly reactive to aldehydes and ketones and can form stable hydrazone bonds. BOC Sciences offers a wide range of PEG derivatives in which the hydrazide PEG linker can be linked to functional groups such as biotin, C18, 4-Arm and 8-Arm. The modified hydrazide PEG can enhance its stability, biocompatibility and other properties, and has a wider range of applications.


Examples of Hydrazide PEG


The functional group of Biotin-PEG-Hydrazide consists of a biotin moiety, a PEG spacer group, and a hydrazide moiety. The biotin moiety is a vitamin that binds strongly to amphiphiles, streptavidins and neutral amphiphiles, making it a useful tool for labeling and purification. The multifunctionality of Biotin-PEG-Hydrazide's functionality makes it an invaluable tool for drug research and development, with a wide range of applications in targeted drug delivery, diagnostics and therapeutic protein modification.


Hydrazide-PEG-NHS (N-hydroxysuccinimide ester) refers to a specific modification of PEG containing both the hydrazide functional group (-NH-NH2) and the NHS ester, which is commonly used as a reaction intermediate in bioconjugate chemistry. They react with primary amines (-NH2) to form stable amide bonds. In the case of Hydrazide-PEG-NHS, the NHS ester group reacts with primary amines present on biomolecules (e.g., proteins or peptides), resulting in covalent binding.


Hydrazide-PEG-Hydrazide is a PEG derivative whose molecular chain segments are hydrazide-functionalized. Hydrazide-PEG-Hydrazide can be used for reversible polyethylene glycolization by reacting with ketones or aldehydes to form an acyl bond, which is pH sensitive. In addition, it can be used to activate carboxylic acids such as succinimide NHS esters.

Hydrazide PEG and Lipid Binding

Hydrazide PEG and lipids can be used in combination to form lipidated hydrazide PEG nanoparticles. In such nanoparticles, hydrazide PEG provides improved stability, biocompatibility and drug release properties, while lipids provide the self-assembling structure of the nanoparticles and the ability to encapsulate the drug. This lipidated hydrazide PEG nanoparticles enable applications such as targeted drug delivery, slow release and enhanced efficacy by controlling the properties and surface modifications of the nanoparticles.

Why Choose Hydrazide PEG as a Linker?

Reaction Specificity

Hydrazide PEG selectively reacts to produce stable hydrazine-ketone bonds. This reaction is highly specific and not susceptible to interference from other functional groups.


Hydrazide bonds are stable covalent bonds that can remain stable in living organisms for long periods of time.


The structure of hydrazide PEG can be adjusted on demand for the length of the PEG chain and the density of the hydrazide groups to meet the requirements of a specific application.

BOC Sciences is a top supplier of PEG and its derivative reagents, offering a wide range of PEG products modified with different groups. These PEG derivatives offer a wide range of functionalities, stability, biocompatibility, etc., and can be used in a variety of applications, including biotechnology, drug discovery, and more. In addition, our skilled scientists are knowledgeable in the development of PEG derivatives and can provide specialized guidance and support for specific applications.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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