PEGylation of Nucleic Acids

In order to help customers' nucleic acid drugs to maximize their effects and enter the market as soon as possible, BOC Sciences has launched a customized PEGylation service. We can realize the PEGylation service of various nucleic acids including DNA, mRNA, siRNA and oligonucleotides. Based on our familiarity with various bioconjugate methods, we have extended our services to all stages of bioconjugate development.

Introduction of Nucleic Acids PEGylation

Nucleic acid-based drugs, such as antisense drugs, aptamers, and siRNAs, have attracted considerable attention as promising therapeutic agents for the treatment of various human diseases; however, they are unstable to enzymatic degradation and rapid renal clearance problems such as can reduce drug effect, limit application. Due to its biocompatibility and inert properties, PEG is widely used in drug development. PEG is considered the material of choice in gene delivery systems and is the gold standard in the field of polymer drug delivery. In the field of nucleic acid delivery, PEG is used for the modification of nucleic acids such as antisense oligonucleotides, aptamers and siRNA, which can stabilize nucleic acids and inhibit rapid clearance from the kidney.

Our Nucleic Acids PEGylation Capabilities

We achieve PEGylation of nucleic acids in a reliable and reproducible manner. Customers can choose from the following service modules according to their needs.

PEGylation Services of DNA

From upstream raw material production and supply to preclinical research on PEGylated DNA design, synthesis, chemical modification, and delivery system development.

PEGylation Services of mRNA

Two service modes, customers provide mRNA or comprehensive PEGylation method development services.

PEGylation Services of siRNA

We offer a wide range of complex PEG derivatives and support multiple conjugation routes.

PEGylation Services of Oligonucleotides

Using this service, clients can obtain therapeutic oligonucleotides with superior properties in the areas of cellular uptake, gene regulatory efficacy, side effect reduction, and biodistribution. We are also able to meet your PEGylation needs from laboratory scale to large scale commercial scale.

A Comprehensive Network of Sites

In order to respond quickly to our customers' needs, we have established a network of sites to handle the PEGylation of nucleic acids on both laboratory and commercial scales. Our network includes: PEG R&D laboratories, cGMP PEGylation manufacturing capabilities, and complete analytical setups.

Quality Assurance

We develop and manufacture a wide range of PEG derivatives with high purity and low polydispersity under our ISO 9001 and ISO 13485 certified quality management system. At the same time, we also follow the ICH Q7A guidelines and operate according to the cGMP protocol.

Advantages of Working with Us

• High-quality raw material supply and flexible batch sizes
• Fully accredited synthesis laboratory and GMP certified manufacturing facility
• Detailed and comprehensive data package for quality analysis, technology transfer and declaration
• Technical assistance for any type of PEGylation according to specific client requirements

BOC Sciences has the technology to prepare polyethylene glycol derivatives with different terminal functional groups and different molecular weights to meet the needs of modifying different nucleic acid drugs with different reactive functional groups. We are able to select the appropriate PEG molecule for your nucleic acid based on factors such as function, PEG structure and reactivity, and formulate optimal PEGylation conditions.

If you are interested in our PEGylation services, please contact us today.