PEGylation of Nucleic Acids
In order to help customers' nucleic acid drugs to maximize their effects and enter the market as soon as possible, BOC Sciences has launched a customized PEGylation service. We can realize the PEGylation service of various nucleic acids including DNA, mRNA, siRNA and oligonucleotides. Based on our familiarity with various bioconjugate methods, we have extended our services to all stages of bioconjugate development.
Introduction of Nucleic Acids PEGylation
Nucleic acid-based drugs, such as antisense drugs, aptamers, and siRNAs, have attracted considerable attention as promising therapeutic agents for the treatment of various human diseases; however, they are unstable to enzymatic degradation and rapid renal clearance problems such as can reduce drug effect, limit application. Due to its biocompatibility and inert properties, PEG is widely used in drug development. PEG is considered the material of choice in gene delivery systems and is the gold standard in the field of polymer drug delivery. In the field of nucleic acid delivery, PEG is used for the modification of nucleic acids such as antisense oligonucleotides, aptamers and siRNA, which can stabilize nucleic acids and inhibit rapid clearance from the kidney.
Our Nucleic Acids PEGylation Capabilities
We achieve PEGylation of nucleic acids in a reliable and reproducible manner. Customers can choose from the following service modules according to their needs.
PEGylation Services of DNA
From upstream raw material production and supply to preclinical research on PEGylated DNA design, synthesis, chemical modification, and delivery system development.
PEGylation Services of mRNA
Two service modes, customers provide mRNA or comprehensive PEGylation method development services.
PEGylation Services of siRNA
We offer a wide range of complex PEG derivatives and support multiple conjugation routes.
PEGylation Services of Oligonucleotides
Using this service, clients can obtain therapeutic oligonucleotides with superior properties in the areas of cellular uptake, gene regulatory efficacy, side effect reduction, and biodistribution. We are also able to meet your PEGylation needs from laboratory scale to large scale commercial scale.
A Comprehensive Network of Sites
In order to respond quickly to our customers' needs, we have established a network of sites to handle the PEGylation of nucleic acids on both laboratory and commercial scales. Our network includes: PEG R&D laboratories, cGMP PEGylation manufacturing capabilities, and complete analytical setups.
Quality Assurance
We develop and manufacture a wide range of PEG derivatives with high purity and low polydispersity under our ISO 9001 and ISO 13485 certified quality management system. At the same time, we also follow the ICH Q7A guidelines and operate according to the cGMP protocol.
Advantages of Working with Us
- High-quality raw material supply and flexible batch sizes
- Fully accredited synthesis laboratory and GMP certified manufacturing facility
- Detailed and comprehensive data package for quality analysis, technology transfer and declaration
- Technical assistance for any type of PEGylation according to specific client requirements
BOC Sciences has the technology to prepare polyethylene glycol derivatives with different terminal functional groups and different molecular weights to meet the needs of modifying different nucleic acid drugs with different reactive functional groups. We are able to select the appropriate PEG molecule for your nucleic acid based on factors such as function, PEG structure and reactivity, and formulate optimal PEGylation conditions.
If you are interested in our PEGylation services, please contact us today.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- Multi-Arm PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Services
- PEGylation Services
- PEGylation Analysis and Method Verification
- Surface Modification and Functionalization
- PEGylated Biodegradable Polymers Synthesis
- Monodisperse PEG Synthesis
- Custom Synthesis PEG Derivatives
- PEG cGMP Manufacture
- PEG Crosslinking Services
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
- Industry News
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS

PEG linkers For Drug
Improved Circulation Half-Life
Learn More
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