PEGylation of Biotin

BOC Sciences, the industry vanguard for cutting-edge biotechnology, holds the reins on the supply of biotin PEG, an incredibly multifaceted compound that brims with a myriad of uses in the life sciences. Biotin PEG represents a type of biotin derivative that receives a glorious transformation via the addition of PEG chains. This revamp, in turn, imbues biotin with enhanced solubility, stability, and biocompatibility, thereby rendering it an unparalleled and supreme molecule for employment in drug delivery, diagnostics, and biotechnology research.

Biotin PEG Classification

Biotin PEG can be classified based on the type of linker and PEG chain used in the synthesis process. Some common types of biotin PEG include succinimidyl biotin PEG, maleimide biotin PEG, and hydrazide biotin PEG. Succinimidyl biotin PEG is one of the most widely used types and is characterized by a succinimidyl ester linker that reacts with primary amines on target molecules. Maleimide biotin PEG, on the other hand, uses a maleimide linker that binds to sulfhydryl groups on target molecules. Hydrazide biotin PEG uses a hydrazide linker that reacts with aldehyde or ketone groups on target molecules.

PEGylation of Biotin

Biotin PEG Synthesis Process

The complex synthesis of biotin PEG entails the careful modification of biotin with PEG chains of varying lengths. The PEG chains, typically secured to the amine group of biotin, are united via a linker molecule, such as succinimidyl or maleimide. The selection of the optimal linker molecule and PEG chain length hinges upon the desired properties of the final product, thereby necessitating a judiciously tailored approach to the process. For example, longer PEG chains can increase the water solubility and reduce immunogenicity, while shorter chains can improve the stability and drug release of biotin conjugates.

Applications of Biotin PEG

Biotin-PEG has a variety of applications in the fields of drug delivery, diagnostics, and biotechnology research. Its modification with PEG chains enhances its solubility, stability, and biocompatibility, making it an ideal molecule for use in various applications. Some of the most common applications of biotin-PEG include:

Targeted Drug Delivery

PEGylation of Biotin

Biotin-PEG can be used to target drugs to specific cells or tissues. To do this, a targeting molecule, such as an antibody or peptide, that can bind to a particular receptor on the target cell is attached to the drug of interest via biotin-PEG conjugation.


In imaging processes like magnetic resonance imaging (MRI) and fluorescence imaging, biotin-PEG can be employed as a contrast agent. This is accomplished by coupling a contrast agent or fluorophore to biotin-PEG, which enables the viewing of particular tissues or cells.

Protein Purification

Biotin-PEG can be used in protein purification techniques such as affinity chromatography. This is accomplished by coupling a ligand that binds specifically to a target protein to biotin-PEG, enabling the purification of the desired protein.

ELISA and Other Immunoassays

Biotin-PEG can be used in enzyme-linked immunosorbent assays (ELISA) and other immunoassays. The detection or measurement of particular proteins or molecules is made possible by conjugating biotin-PEG to an antibody or antigen.

Cell Labeling

Biotin-PEG can be used to label cells for tracking and imaging purposes. This is achieved by conjugating biotin-PEG to a cell-permeable compound that binds specifically to intracellular proteins or organelles.

Biotin PEG Manufacturing Capacity

BOC Sciences has a strong manufacturing capacity for biotin PEG and related products. We offer a wide range of biotin PEG derivatives with different PEG chain lengths and linkers, as well as custom synthesis services to meet specific customer needs. Our cGMP manufacturing process is carried out under strict quality control standards to ensure the highest quality and purity of our products. We also offer technical support and expertise to help customers with their biotin PEG applications.

Synthetic Highlights of Our PEGylated Biotin

  • Increased solubility: PEGylation can increase the solubility of biotin in aqueous solutions, which can improve its stability and bioavailability.
  • Reduced immunogenicity: PEGylation can reduce the immunogenicity of biotin, which can decrease the risk of adverse immune reactions.
  • Prolonged half-life: PEGylation can increase the half-life of biotin in the bloodstream, which can improve its efficacy and reduce the frequency of dosing.
  • Enhanced tissue penetration: PEGylation can improve the tissue penetration of biotin, which can increase its effectiveness in targeting specific cells or tissues.
  • Reduced clearance: PEGylation can reduce the clearance of biotin from the body, which can improve its therapeutic potential.

Our Biotin-PEG Finished Products

Product NameMolecular WeightProduct NameMolecular Weight
4-Arm PEG-BiotinMW 2k-20KBiotin-PEG-ACMW 1k-10k
8-Arm PEG-BiotinMW 10k-40KBiotin-PEG-COOHMW 1k-10k
Biotin-PEG-MALMW 1k-10kBiotin-PEG-OHMW 1k-10k
Biotin-PEG-NH2MW 1k-10kBiotin-PEG-SCMMW 1k-10k
Biotin-PEG-NHSMW 1k-4kBiotin-PEG-SHMW 1k-10k
Biotin-PEG-SilaneMW 1k-10kmPEG-BiotinMW 550-40K

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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