Y-shaped PEGs Synthesis
BOC Sciences supplies global customers with high quality activated Y-shaped PEGs derivatives with high purity and low polydispersity. Our PEG custom synthesis services are rigorously tested to meet superior quality and R&D needs at competitive prices. Our proprietary Y-shaped PEG has been used for the pegylation of nanoparticles, proteins and peptides, antibodies, carbohydrates and biotin. We offer opportunities for cGMP grade PEG derivatives and bulk orders through custom synthesis to meet customers' specific quality requirements.
Introduction of Y-shaped PEGs
PEG can be synthesized via anionic polymerization of ethylene oxide and any hydroxyl initiators. Hydroxyl group could be from water, ethylene glycol, or any diols, and they can also be derived from epoxyethane by ring-opening polymerization. Usually, the polymerization process produces a family of PEG molecules with a wide Gaussian distribution of molecular weights. However, because PEG bearing only two functional groups limits further derivatization with other residues or targeting ligands, commercial PEGs are available with different degrees of polymerization and activated functional groups.
Fig. 1. Y-shaped PEGylation of proteins.
Branched polyethylene glycol derivatives include Y-shaped PEG derivatives and U-shaped PEG derivatives, which are connected by two straight-chain methoxy polyethylene glycol derivatives with the N atom as the center. The three-dimensional structure of Y-shaped PEG derivatives is bulky and has greater steric hindrance than single-chain polyethylene glycol derivatives. Y-shaped PEG can be used to react with amino groups in proteins or other biomacromolecules, such as coupling with amino groups on lysine in protein molecules, prolonging the half-life of protein molecules in vivo and reducing immunogenicity. In addition, Y-shaped PEG derivatives are chemically purified during synthesis and are essentially free of activated bifunctional PEG by-products.
Application of Y-shaped PEGs
Y-shaped PEGs has broad applications in the PEGylation of cancer therapeutics, cocaine esterase, antibiotics, antivirals, nucleotides, Cp40 and rhGH for the treatment of rheumatoid diseases, transplant health and tissue growth. Compared with linear PEG-modified drugs and natural drugs, drugs modified with Y-shaped PEGs showed better stability to enzymatic digestion, temperature and pH. Pegylation with Y-shaped PEGs can improve the drug's PK/PD profile. Reversible Y-shaped PEGylation of drugs and drug delivery systems increases activity and targeting compared to irreversible Y-shaped PEGylation.
Activated Y-shaped PEG derivatives from BOC Sciences with high purity and low polydispersity are suitable for amine PEGylation, thiol PEGylation, flourescent PEGylation, C-terminal PEGylation, and other applications. Our custom PEG synthesis services meet the PEGylation needs of the pharmaceutical, biotech, medical device, diagnostic and emerging chemical specialty markets from laboratory scale to large-scale commercial use. If you are interested in our PEG synthesis service, please contact us for more information.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- Multi-Arm PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Services
- PEGylation Services
- PEGylation Analysis and Method Verification
- Surface Modification and Functionalization
- PEGylated Biodegradable Polymers Synthesis
- Monodisperse PEG Synthesis
- Custom Synthesis PEG Derivatives
- PEG cGMP Manufacture
- PEG Crosslinking Services
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
- Industry News
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS

PEG linkers For Drug
Improved Circulation Half-Life
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