Nitrophenyl carbonate (NPC) PEG

PEG is a biocompatible, hydrophilic polymer that modifies the solubility, stability, and pharmacokinetics of the attached molecule. Pharmaceutical companies frequently utilize PEGylation to improve the therapeutic efficacy of their products and lessen their immunogenicity. Moreover, it can increase the bioavailability of medications, lengthen their duration in the body, and lessen their toxicity. Many medications, including proteins, peptides, antibodies, and small compounds, have been subjected to PEGylation. Researchers may select the best PEG for their unique needs from BOC Sciences' extensive selection of PEG products, which include various molecular weights, functional groups, and PEG derivatives. By stringent quality control procedures, we guarantee the excellent quality of PEG goods and provide bulk orders.

What is Nitrophenyl carbonate (NPC)?

Nitrophenyl carbonate (NPC) is a chemical compound with the molecular formula C7H5NO5. p-nitrophenyl carbonate and 4-nitrophenyl carbonate are other names for it. NPC is a colorless to light yellow crystalline solid that is soluble in acetone and methanol, among other organic solvents. NPC is primarily employed as a reagent in the synthesis of organic compounds, particularly in the production of carbamates and carbonates. It frequently serves as a protective group for amines and alcohols, enabling the transition of certain functional groups. Many medicines, agrochemicals, and other organic substances may be synthesized using NPCs.

4-Arm PEG-NPC

4-arm PEG- NPC is a molecule that finds applications in drug delivery and bioconjugation. It is derived from a 4-arm PEG structure and contains nitrophenyl carbonate groups. The 4-arm PEG structure of 4-arm PEG-NPC provides multiple attachment sites, allowing simultaneous conjugation of multiple drugs or biomolecules. This could lead to the formation of multifunctional drug delivery systems or bioconjugates with enhanced therapeutic properties. By utilizing 4-arm PEG-NPCs, researchers can develop complex and multifunctional drug delivery systems that offer controlled release, improved targeting, and prolonged circulation in vivo.

mPEG-NPC

mPEG-NPC is a compound used in the fields of drug delivery and bioconjugation. It is derived from methoxypolyethylene glycol (mPEG) and contains nitrophenyl carbonate groups. mPEG-NPCs are commonly used as linker molecules to bind drugs or biomolecules (such as proteins or peptides) to PEG chains. The nitrophenyl carbonate group reacts with primary amines present in biomolecules to form stable covalent bonds. This conjugation strategy helps to improve the solubility, stability, and pharmacokinetics of drugs or biomolecules. The resulting mPEG-NPC-drug or mPEG-NPC-biomolecule conjugates can be used for targeted drug delivery, prolonged drug release, or enhanced therapeutic efficacy. Among them, the PEG component helps to reduce immunogenicity and increase circulation time in the body.

Advantages of Our PEG Supply

• Rich experience in research and development, accumulated more than a number of project cases;
• Provide super multifunctional modification options (MAL, OPSS, SPDP, FITC, Biotin, silane, NPC, COOH, DSPE, etc.)
• Good performance, high purity, product polymerization dispersion (PDI) less than 1.05
• Wide range of molecular weight distribution, 500-200,000 can be satisfied
• Simplified production process, low impurities and stable quality
• Mass production, cost controllable, customized packaging
• Complete customer special customization needs in a short period