mPEG-Propionaldehyde

Synonyms: Methoxy polyethylene glycol-Propionaldehyde

Methoxy polyethylene glycol-Propionaldehyde (mPEG- Propionaldehyde) is a modifier with one end of the methoxy group and the other end of the propionaldehyde derivative. It is usually white or yellowish liquid, semi-solid or solid, depending on the molecular weight. In the presence of sodium cyanobohydride, it can react with the primary amine of the N-terminal amino bond of the active drug. Aldehyde group is different from other electrophilic active groups, it only reacts with amine group, so it is mainly used in N-terminal specific PEGylation. Although the reaction activity of aldehyde group is lower than that of NHS active ester, it has mild reaction conditions (pH 6-9.5 (the most range is ph5-10), 6-24 hours), and is easy to connect peg with protein or other materials. It provides conditions for medical research, drug delivery, nanotechnology and new materials research, cell culture and ligand research.