Bile Acid Standards
Cat. No. | Product Name | CAS No. | |
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BPG-3113 | 25-Hydroxy Cholesterol-[d6] | 88247-69-2 | Inquiry |
BPG-3114 | 27-Hydroxy Cholesterol-[d6] | 1246302-95-3 | Inquiry |
BPG-3115 | C15 Ceramide-d7 (d18:1-d7/15:0) | Inquiry | |
BPG-3116 | 15:0-18:1 PA-[d7] Sodium salt | 2260669-46-1 | Inquiry |
BPG-3117 | 18:1 SM (d18:1/18:1(9Z)) | 108392-10-5 | Inquiry |
BPG-3118 | C24:1 Ceramide (d18:1/24:1(15Z))-[d7] | 1840942-16-6 | Inquiry |
BPG-3119 | 15:0-18:1-15:0 TG-[d7] | 2097561-17-4 | Inquiry |
BPG-3120 | Cholesterol-[25,26,26,26,27,27,27-d7] | 83199-47-7 | Inquiry |
BPG-3121 | 15:0-18:1 PC-[d7] | 2097561-16-3 | Inquiry |
BPG-3122 | 15:0-18:1 PE-[d7] | 2097561-15-2 | Inquiry |
BPG-3123 | 7α-Hydroxy-4-cholesten-3-one-[d7] | 2260669-17-6 | Inquiry |
BPG-3124 | 15:0-18:1 PG-[d7] Sodium salt | 2260669-42-7 | Inquiry |
BPG-3125 | 7-Keto Cholesterol-[d7] | 127684-08-6 | Inquiry |
BPG-3126 | 7β-Hydroxycholesterol-[25,26,26,26,27,27,27-d7] | 349553-97-5 | Inquiry |
BPG-3127 | pacFA Ceramide | 1262788-58-8 | Inquiry |
BPG-3153 | C15 Ceramide (d18:1/15:0) | 67492-15-3 | Inquiry |
BOC Sciences offers a comprehensive line of bile acid standards to complement primary, secondary or conjugated bile acid studies. These quantitative standards are characterized at defined concentrations and pre-packaged in unit containers. The standards are supplied with detailed certificates of analysis and their stability is monitored by our quality control staff.
What is Bile Acid?
Bile acids (BA) are potent digestive surfactants that facilitate lipid absorption. Bile acids are now recognized as hormones involved in the regulation of various metabolic processes. Bile acids not only regulate their own synthesis and enterohepatic circulation, but also triglycerides, cholesterol, glucose and energy homeostasis. Current metabolomics and lipidomics studies aim to provide new insights into the mechanisms of bile acid signaling in the regulation of lipid metabolism and maintenance of lipid homeostasis.
Fig. 1. Chemical structures of the common bile acids in mammals (Steroids. 2021, 173: 108879).
Characteristics of Bile Acid
Digestive aid. Bile acid products can bind to fats during digestion and help emulsify and break down fats, making them easier to be broken down by gastric acid and gastric enzymes, thus promoting the absorption and utilization of fats.
Promote fat metabolism. Bile acids can affect fat metabolism and breakdown by regulating cholesterol synthesis and cholesterol metabolism pathways, thus having an impact on weight control and weight loss.
Bile acid replacement therapy. Certain diseases or conditions may result in insufficient or abnormal metabolism of bile acids, which may affect fat digestion and absorption. In such cases, bile acid products may be used as bile acid replacement therapy to help restore normal fat digestion and absorption function.
Bile Acid Analysis
Bile acids are synthesized in the liver and play an important role in cholesterol homeostasis, vitamin and lipid absorption, and a variety of key metabolic processes. BA analysis is an important area of research in a variety of settings, including clinical laboratories, as well as in ADME and toxicology studies. Abnormalities in BA biosynthesis and accumulation have been linked to a wide range of human diseases and mechanisms that cause hepatotoxicity, including drug-induced cholestasis.
Applications of Bile Acid
Drug Research for Primary Hyperlipidemia
Serum levels of total bile acids are positively correlated with triglyceride and cholesterol levels in patients with hyperlipidemia, and many hypertriglyceridemic patients have bile acid levels at high levels. The application of bile acid standards to analyze the distribution of bile acids in the plasma of patients with primary hyperlipidemia can provide a strong objective basis for the treatment and dietary adjustment of patients.
Drug Development for Gallstones
The bile acid molecule contains both hydrophilic groups (hydroxyl, carboxyl or sulfonic acid groups) and hydrophobic groups (methyl, heterocyclic), which can form complexing micelles with phospholipids and cholesterol in bile. However, when the bile acid content changes, the complex micelles become unstable and gallstones may form. Therefore, it is important to analyze the changes of bile acid type and content in living organisms with bile acid standards for the prevention and treatment of gallstones.
Drug Delivery System
Due to the special biocompatibility of bile acids and the solubility of bile acids, bile acids can be used as drug carriers or delivery systems to help improve the solubility, absorption and bioavailability of drugs.
Fig. 2. Bile acids as drug carrier system (Frontiers in Life Science. 2013, 7(3-4): 112-122).
Based on the rigors of the business and regulatory requirements for the biopharmaceutical industry, BOC Sciences has been a leader in product compliance and certification. We offer lipid-related products, so please feel free to contact us if you have a need.
References
- Lei, K. et al. Research progress in the application of bile acid-drug conjugates: A "trojan horse" strategy. Steroids. 2021, 173: 108879.
- Stojančević, M. et al. Application of bile acids in drug formulation and delivery. Frontiers in Life Science. 2013, 7(3-4): 112-122.
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PEG Raw Materials
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Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
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