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Lipid Synthesis Services

Lipids are a broad family of organic molecules with a large number of important functions in biological processes and industrial applications. BOC Sciences provides lipid synthesis services to fit the individual requirements of researchers, pharmaceutical companies, and other industries. Our bespoke lipid synthesis solutions by BOC Sciences include lipid molecules like fatty acids, phospholipids, glycolipids, sphingolipids and sterols. These lipids can be prepared in the purest form and in quantities from milligrams to kilograms as per customer demand.

What is a Lipid?

Lipids are a broad class of organic molecules that are relatively poorly water-soluble but highly soluble in organic solvents. They are made of carbon, hydrogen, oxygen and, in some, phosphorus, nitrogen or sulfur. Lipids serve biologically essential roles such as energy storage, membrane physiology and signaling. The primary ones are fatty acids, glycerides, phospholipids and steroids, which all play roles in the production of energy, cell membranes and hormones. The special nature of lipids renders them essential for medicines, food and cosmetics. They facilitate the delivery of medicines, act as emulsifiers in food, and provide moisturizing and stabilizing properties in cosmetics. Lipids are also used to make biofuels, further evidence of their flexibility and industrial use.

What Can We Offer?

BOC Sciences’ custom lipid synthesis services are a cost-effective and effective way for scientists and industry to get the highest-quality lipids for diverse applications. In our custom synthesis, customers can customize the structure modification, functional groups or isotopic labeling according to their specific research requirements. This adaptability allows scientists to obtain lipids that fit their application, including drug discovery, lipidomics and cell biology. Our experience, cutting-edge equipment and dedication to customer satisfaction has made us an integral lipid synthesis partner.

Fatty acid synthesis	Triglyceride synthesis	Phospholipid synthesis
Steroid synthesis	Glycolipid synthesis	PEGylated lipid synthesis
Fluorescent lipid synthesis	Biotinylated lipid synthesis	Halogenated lipid synthesis
Cationic lipid synthesis	Cholesterol synthesis	Sphingolipid synthesis
Neutral lipid synthesis	Branched lipid synthesis	Ionizable lipid synthesis

Why Choose BOC Sciences?

Custom Lipid Formulations Surface labeling, PEGylation, fluorescent and other liposome formulations.
cGMP Manufacturing Synthetic organic laboratories and manufacturing facilities for product development.
Process Development Process scale-up, analytical development and validation.
Advanced Equipment cGMP analytical laboratory for product testing and stability studies.
Cost-effective Solution Guidance from project planning and design to product characterization and analysis.

Lipid Synthesis Services

Lipids can be synthesized from a variety of starting materials, such as fatty acids, alcohols and glycerol. The choice of starting materials depends on the desired lipid structure and properties. The starting material is usually activated to make it more reactive to subsequent reactions. For example, fatty acids can be activated by converting them into fatty acid esters or fatty acyl chlorides. Then, the activated starting materials can be linked together by esterification, transesterification or condensation to form a lipid backbone. In addition, enzymes such as lipases and phospholipases can also be used for lipid synthesis by enzymatic methods.

Enzymatic Synthesis
Enzyme-catalyzed lipid synthesis refers to the process in which enzymes promote the formation of lipids through chemical reactions. An example of an enzyme catalyzing lipid synthesis is the formation of triglycerides. The process involves the esterification of three fatty acids with a glycerol molecule to form a triglyceride molecule. Enzymes called acyltransferases catalyze this reaction by transferring fatty acid chains onto the glycerol backbone. BOC Sciences has a team of experienced scientists with extensive expertise in enzymatic lipid synthesis. Our in-depth knowledge of lipid chemistry and enzymatic reactions ensures efficient and successful lipid synthesis. In addition, BOC Sciences' enzymatic lipid synthesis service is highly scalable and can produce various quantities of lipids. Whether customers require small research quantities or larger quantities for industrial applications, we have you covered.
Chemical Synthesis
BOC Sciences has a team of experienced chemists and scientists specializing in lipid chemical synthesis. We have in-depth knowledge and expertise in the synthesis of various lipids including but not limited to phospholipids, glycolipids, sphingolipids, sterols and fatty acids. We can synthesize lipids with varying chain lengths, degrees of unsaturation, and functional groups, enabling customers to obtain lipids tailored to their research needs. We are committed to following strict quality control procedures to ensure the purity and integrity of our synthetic lipids. Advanced analytical techniques such as nuclear magnetic resonance and mass spectrometry are used to verify the structure and purity of the product.
Lipid Biosynthesis
Lipid biosynthesis can occur in different cellular compartments, including the cytoplasm, endoplasmic reticulum (ER), and mitochondria. This process involves a variety of enzymatic reactions and is regulated by a variety of factors. BOC Sciences offers custom lipid biosynthesis services to meet the specific needs of researchers. Our high-quality lipid products, such as fatty acids, phospholipids, sphingolipids and sterols, can be synthesized to the required specifications. We are committed to offering competitive pricing and flexible options to suit different research budgets.
Lipid Extraction
At BOC Sciences, we also offer comprehensive lipid extraction services. Our team has extensive experience working with a variety of sample types, including tissues, cells, and biological fluids, extracting lipids from complex biological matrices and performing detailed analyzes to identify and quantify individual lipid species. Our lipid extraction services are suitable for a variety of research applications, including lipidomics, metabolomics and biomarker discovery. At the same time, we can extract lipids from a variety of sample types, including blood, plasma, serum, tissue, and cells.

Lipid Analysis

Lipid analysis is a core technique for studying the composition, structure, and function of lipids, covering a wide range of types from natural sources to synthetic lipids. Key analytical methods include gas chromatography (GC), high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR), which are used to identify lipid species, molecular structures, and physicochemical properties. Additionally, infrared spectroscopy (IR) and Raman spectroscopy are commonly applied to investigate lipid molecular interactions and biomembrane characteristics. Lipid analysis is critical in industries such as food, pharmaceuticals, and cosmetics, facilitating the detection of lipid purity, content, and distribution in complex systems. This provides essential data for research, development, and quality control. BOC Sciences offers comprehensive analysis and characterization services. By utilizing these analytical techniques, we ensure the high quality and purity of the synthetic lipids we supply. This helps our customers have confidence in the performance and reliability of our products. Available analytical tools and services include, but are not limited to:

Instruments	Analysis items
Nuclear magnetic resonance (NMR)	Lipid lamellar analysis
Mass spectrometry (MS)	Lipid content analysis
High performance liquid chromatography (HPLC)	Lipid particle size analysis
Thin layer chromatography (TLC)	Lipid permeability analysis
Gas chromatography (GC)	Lipid zeta potential analysis
Fourier transform infrared spectroscopy (FT-IR)	Lipid optical rotation analysis
UV/VIS spectroscopy	Lipid formulation stability analysis
Capillary gas chromatography/flame ionization detection (GC/FID)	Lipid encapsulation efficiency analysis

BOC Sciences specializes not only in high-precision lipid analysis services but also in comprehensive fatty acid analysis and lipidomics. With advanced instruments and techniques such as GC-MS, LC-MS, and NMR, we precisely characterize fatty acid composition and structural features, revealing lipidomic dynamics. We provide end-to-end support from lipid separation and quantification to data analysis, advancing drug development, food safety testing, and metabolic research, offering reliable solutions for scientific exploration and industrial innovation.

Fatty Acid Analysis

Lipidomics Analysis

Lipid Modification

The primary goal of lipid modification technology is to enhance the functional properties of lipids, such as stability, solubility, and bioavailability. Lipid modification techniques can include processes such as hydrogenation, transesterification, fractionation, and enzymatic modification. BOC Sciences' lipid modification technology is applicable to a wide variety of drugs and therapeutics. It can be used with small molecules, peptides, proteins and nucleic acids, making it a versatile drug delivery platform. We can tailor lipid modifications to meet specific drug delivery requirements, including tailoring the lipid composition, size and surface properties of lipid carriers to optimize drug delivery for different applications. Our lipid modification technology has the advantages of enhanced drug delivery, improved drug efficacy, improved drug safety, extended drug half-life, multifunctionality, scalability and customization.

Lipid Formulation

Lipid formulation involves the development of functional lipid-based systems for applications in drug delivery, cosmetics, and functional foods. This process includes selecting lipids, optimizing proportions, and evaluating compatibility with other components to ensure stability and bioavailability. Lipid formulation techniques encompass emulsification, nanonization, and surface modifications, improving solubility of poorly soluble drugs, enhancing biomembrane permeability, and optimizing drug targeting. Rational design enables controlled and sustained release, offering innovative solutions for multidisciplinary product development.

Preparation
Cosmetics
Fluorescent Dyes
Gene Therapy
Vaccines
Drug Delivery

Lipid Excipient

Lipid excipients are lipid-based compounds used as carriers or functional components in formulations, including phospholipids, cholesterol, fatty acids, and their derivatives. These excipients regulate the physicochemical properties of formulations, such as solubility, stability, and drug release. For example, phospholipids are widely used in liposome and microemulsion formulations, while cholesterol enhances membrane rigidity and stability. Lipid excipients offer unique advantages in drug delivery, improving solubility and targeting while reducing toxicity, supporting biopharmaceutical and cosmetic innovations.

Request Custom cGMP Lipids

Lipid Nanoparticles

Lipid nanoparticles (LNPs) are nanoscale drug delivery carriers made of lipids, characterized by excellent biocompatibility and biodegradability. They can encapsulate hydrophilic or lipophilic drugs and achieve targeted delivery through surface modification. Common types include solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). LNPs demonstrate significant potential in vaccine development, gene therapy, and cancer treatment due to their stability, high drug-loading capacity, and controlled-release properties. Their small size and high surface area promote in vivo distribution and cellular uptake, enhancing therapeutic efficacy.

Lipid Nanoparticle Synthesis
Liposome Preparation
Liposome Encapsulation

Lipid nanoparticles are synthesized using techniques such as high-pressure homogenization, ultrasonic emulsification, solvent evaporation, and microfluidics. By adjusting the ratios of lipids, surfactants, and drugs, synthesis processes optimize particle size, shape, and drug-loading capacity. Microfluidics, as an emerging technique, is gaining attention for its precise control and reproducibility. Key process parameters such as temperature, shear rate, and solvent choice ensure the physical and chemical stability of nanoparticles.
Liposomes, bilayer vesicular structures made of phospholipids and cholesterol, are extensively used in drug delivery and cosmetics. Preparation methods include thin-film evaporation, ultrasonic dispersion, reverse-phase evaporation, and freeze-drying. By adjusting parameters like lipid-to-cholesterol ratio, pH, and temperature, liposome size, encapsulation efficiency, and release profiles can be tailored. Modern microfluidic technologies significantly enhance uniformity and scalability, supporting industrial applications of liposomes.
Liposome encapsulation involves using liposomes as carriers to encapsulate active ingredients, with applications in drug delivery, gene therapy, cosmetics, and nutraceuticals. Liposomes consist of a phospholipid bilayer with a dual-phase structure, enabling the encapsulation of both hydrophilic and hydrophobic molecules. Hydrophilic compounds are encapsulated in the aqueous core, while hydrophobic molecules integrate into the bilayer structure.

Lipid cGMP Manufacturing

In drug delivery systems such as liposomes and lipid nanoparticles, lipids serve as critical components requiring highly pure and controlled manufacturing processes to meet the stringent requirements of regulatory agencies. cGMP production emphasizes comprehensive quality control throughout the process, including raw material selection, production process optimization, sterile operations, and final product testing, to ensure the safety, efficacy, and consistency of lipid products. BOC Sciences is equipped with advanced cGMP facilities and comprehensive technical capabilities, offering high-quality lipid custom synthesis, large-scale production, and process development services. The company strictly adheres to cGMP standards, covering the entire process from research and development to commercial production, ensuring compliance with international pharmaceutical regulations.

Lipids and Lipid Derivatives

Lipids can be classified based on their chemical structure and function into simple lipids, compound lipids, derived lipids, and sphingolipids. Simple lipids, such as triglycerides and waxes, consist primarily of fatty acids esterified with alcohols and serve as the primary energy storage form in organisms, providing insulation and waterproofing in some species. Compound lipids, including phospholipids and glycolipids, contain fatty acids as well as other functional groups like phosphate or sugar moieties. These lipids are vital components of cell membranes, ensuring structural stability and facilitating cell signaling. Derived lipids include steroids and fat-soluble vitamins; steroids like cholesterol are key components of cell membranes, regulating fluidity and serving as precursors for hormone synthesis, while fat-soluble vitamins such as vitamins A, D, E, and K play essential roles in growth, metabolism, and antioxidation. Sphingolipids, composed of sphingosine and fatty acids, are complex lipids predominantly found in neural tissues, playing critical roles in signal transduction and cell recognition. The diversity in lipid classification underpins their multifaceted functions in living organisms, ranging from energy storage to the regulation of cellular signals, highlighting their biological and industrial significance.

Whether you are studying the role of lipids in disease, developing new treatments for metabolic disorders, or exploring the potential of lipids as biomarkers, we are here to support you every step of the way. Contact us today to learn more about our lipid synthesis services and how we can help you with your research project.

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Lipid Synthesis Services

What Can We Offer?

Why Choose BOC Sciences?

Lipid Synthesis Services

Enzymatic Synthesis

Chemical Synthesis

Lipid Biosynthesis