Lipid Synthesis Services

BOC Sciences is a leading provider of custom lipid synthesis services. Lipids are a diverse class of organic compounds that play important roles in a variety of biological processes. BOC Sciences offers lipid synthesis solutions tailored to meet the specific needs of researchers, pharmaceutical companies, and other industries. BOC Sciences' custom lipid synthesis services include the synthesis of various lipid molecules such as fatty acids, phospholipids, glycolipids, sphingolipids, and sterols. These lipids can be synthesized in high purity and in various quantities, from milligrams to kilograms, according to customer requirements.

What is Lipid Synthesis?

Lipids can be synthesized from a variety of starting materials, such as fatty acids, alcohols and glycerol. The choice of starting materials depends on the desired lipid structure and properties. The starting material is usually activated to make it more reactive to subsequent reactions. For example, fatty acids can be activated by converting them into fatty acid esters or fatty acyl chlorides. Then, the activated starting materials can be linked together by esterification, transesterification or condensation to form a lipid backbone. In addition, enzymes such as lipases and phospholipases can also be used for lipid synthesis by enzymatic methods.

Fig. 1. Lipid molecule structure.

Site of Lipid Synthesis

In organisms, lipid synthesis occurs primarily in the endoplasmic reticulum (ER) and cytoplasm. The endoplasmic reticulum is divided into two regions: rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER). Lipid synthesis occurs primarily in the SER. Within the SER, lipid synthesis is carried out by a series of enzymes that catalyze the formation of various lipids, including phospholipids, cholesterol, and triglycerides. These enzymes are embedded within the SER membrane and work together in a coordinated manner to synthesize lipids from precursor molecules such as fatty acids and glycerol. In the cytoplasm, the process of lipid synthesis is regulated by hormones such as insulin and glucagon, which control the uptake and storage of fatty acids in the form of triglycerides.

Our Lipid Synthesis Services

Chemical Synthesis

BOC Sciences has a team of experienced chemists and scientists specializing in lipid chemical synthesis. We have in-depth knowledge and expertise in the synthesis of various lipids including but not limited to phospholipids, glycolipids, sphingolipids, sterols and fatty acids. We can synthesize lipids with varying chain lengths, degrees of unsaturation, and functional groups, enabling customers to obtain lipids tailored to their research needs. We are committed to following strict quality control procedures to ensure the purity and integrity of our synthetic lipids. Advanced analytical techniques such as nuclear magnetic resonance and mass spectrometry are used to verify the structure and purity of the product.

Enzymatic Synthesis

Enzyme-catalyzed lipid synthesis refers to the process in which enzymes promote the formation of lipids through chemical reactions. An example of an enzyme catalyzing lipid synthesis is the formation of triglycerides. The process involves the esterification of three fatty acids with a glycerol molecule to form a triglyceride molecule. Enzymes called acyltransferases catalyze this reaction by transferring fatty acid chains onto the glycerol backbone. BOC Sciences has a team of experienced scientists with extensive expertise in enzymatic lipid synthesis. Our in-depth knowledge of lipid chemistry and enzymatic reactions ensures efficient and successful lipid synthesis. In addition, BOC Sciences' enzymatic lipid synthesis service is highly scalable and can produce various quantities of lipids. Whether customers require small research quantities or larger quantities for industrial applications, we have you covered.

Lipid Biosynthesis

Lipid biosynthesis can occur in different cellular compartments, including the cytoplasm, endoplasmic reticulum (ER), and mitochondria. This process involves a variety of enzymatic reactions and is regulated by a variety of factors. BOC Sciences offers custom lipid biosynthesis services to meet the specific needs of researchers. Our high-quality lipid products, such as fatty acids, phospholipids, sphingolipids and sterols, can be synthesized to the required specifications. We are committed to offering competitive pricing and flexible options to suit different research budgets.

Lipid Modification Services

The primary goal of lipid modification technology is to enhance the functional properties of lipids, such as stability, solubility, and bioavailability. Lipid modification techniques can include processes such as hydrogenation, transesterification, fractionation, and enzymatic modification. BOC Sciences' lipid modification technology is applicable to a wide variety of drugs and therapeutics. It can be used with small molecules, peptides, proteins and nucleic acids, making it a versatile drug delivery platform. We can tailor lipid modifications to meet specific drug delivery requirements, including tailoring the lipid composition, size and surface properties of lipid carriers to optimize drug delivery for different applications. Our lipid modification technology has the advantages of enhanced drug delivery, improved drug efficacy, improved drug safety, extended drug half-life, multifunctionality, scalability and customization.

Lipid Extraction Services

At BOC Sciences, we also offer comprehensive lipid extraction services. Our team has extensive experience working with a variety of sample types, including tissues, cells, and biological fluids, extracting lipids from complex biological matrices and performing detailed analyzes to identify and quantify individual lipid species. Our lipid extraction services are suitable for a variety of research applications, including lipidomics, metabolomics and biomarker discovery. At the same time, we can extract lipids from a variety of sample types, including blood, plasma, serum, tissue, and cells.

Lipid Analysis and Characterization

BOC Sciences also offers comprehensive analysis and characterization services. By utilizing these analytical techniques, we ensure the high quality and purity of the synthetic lipids we supply. This helps our customers have confidence in the performance and reliability of our products. Available analytical tools and services include, but are not limited to:

What Can We Offer?

BOC Sciences' custom lipid synthesis services provide researchers and industry with reliable and efficient solutions to obtain high-quality lipids suitable for a wide range of applications. Our custom synthesis allows customers to specify desired structural modifications, functional groups or isotopic labels based on their unique research needs. This flexibility enables researchers to obtain lipids tailored to their specific applications, such as drug discovery, lipidomics, and cell biology research. Our expertise, state-of-the-art equipment, and commitment to customer satisfaction make us a trusted partner in the field of lipid synthesis.

Why Choose BOC Sciences?

• Custom lipid formulations: Surface labeling, PEGylation, fluorescent and other liposome formulations.
• cGMP manufacturing and facilities: Synthetic organic laboratories and manufacturing facilities for product development.
• Advanced analytical equipment and technology: cGMP analytical laboratory for product testing and stability studies.
• Synthetic process development: Process scale-up, analytical development and validation (non-cGMP and cGMP).
• Commitment to quality and reliability: Committed to producing lipid products of the highest purity and quality.
• Flexibility and customization capabilities: Provides a wide range of lipid custom synthesis, scale-up synthesis and process optimization.
• Cost-effective solution: Saves time and resources on in-house synthesis work.
• Expertise and technical support: Guidance from project planning and design to product characterization and analysis.

Whether you are studying the role of lipids in disease, developing new treatments for metabolic disorders, or exploring the potential of lipids as biomarkers, we are here to support you every step of the way. Contact us today to learn more about our lipid synthesis services and how we can help you with your research project.