Hydroxyl(-OH) PEG

Hydroxyl PEG (OH PEG) is a polyethylene glycol compound with hydroxyl functional groups. Hydroxyl PEG is reactive and can be chemically reacted with other compounds or biomolecules for modification and functionalization of PEG. Hydroxy PEG can be used to construct biomaterials such as hydrogels, polymer microspheres and scaffold materials. By adjusting the molecular weight and concentration of hydroxy PEG, the physical properties, biocompatibility and degradation properties of the materials can be modulated to meet specific tissue engineering and biomedical application requirements.

Stabilization of nanoparticles with hydroxyl-PEG-phosphonic acidFig. 1. Stabilization of nanoparticles with hydroxyl-PEG-phosphonic acid (Langmuir. 2019, 35(29): 9474-9482).

Examples of Hydroxyl PEG

Amine PEG Hydroxyl

Amine PEG Hydroxyl is a heterobifunctional PEG. Heterobifunctional hydroxy PEG amine products are commonly used as crosslinking agents or as spacer groups between two different chemical entities. The PEG portion of the heterobifunctional PEG derivative provides water solubility, biocompatibility and flexibility.


OPSS-PEG-OH has an OPSS and a hydroxyl group at each end of the molecular chain and is a linear heterofunctional PEG reagent. It is a useful cross-linking reagent for PEG spacers. OPSS stands for o-pyridyl disulfide or o-pyridyl disulfide, which reacts with thiols and sulfhydryl groups to form S-S bonds. Through the pyridyl disulfide bond, OPSS-PEG-OH can selectively react with sulfhydryl groups to form a stable disulfide bond while releasing the thiol pyridyl group. Through this reaction, it can modify biomolecules or other materials.


C18-PEG-OH is a PEG derivative modifier with a C18 hydrocarbon chain on one end and a hydroxyethyl group on the other. The simultaneous presence of polar and non-polar groups makes it a useful amphiphilic surfactant. As a PEG modifier, C18-PEG-OH helps to improve the solubility and stability of modified biomolecules while reducing the immunogenicity of peptides and proteins and inhibiting the non-specific binding of charged molecules on the modified surface.

How Hydroxyl PEG Derivatives are Prepared?

Step 1: Carboxyl Group Introduction

Carboxyl group introduction requires choosing a suitable polyethylene glycol as the starting material and mixing this starting material with hydroxyl reagent to react. After hydroxylation reaction, the crude product is purified to obtain the target product.

Step 2: Post-hydroxylation Modification

After obtaining the hydroxylated polyethylene glycol, the hydroxylated PEG is modified by reacting it with the groups to be modified (amino group, carbon chain, etc.).

Advantages of Hydroxyl PEG

Hydroxyl PEG has the following advantages as a PEG derivative, in addition to biocompatibility, ease of modification, high stability, and structural modification.

Multifunctional Splice Sites

The hydroxyl group of OH-PEG provides multiple sites for the affixation of various functional groups, which can be modified by chemical reactions such as esterification, amidation or etherification. The modified PEG derivatives can then be attached to targeted ligands, drug molecules, and other substances to enhance the development of targeted drug delivery systems or biomaterials.

Invisible Properties

Hydroxy PEG is hydrophilic and can reduce interactions with proteins and cells by forming a hydrated layer, thereby reducing immune recognition and clearance by the body's defense mechanisms.

BOC Sciences has strong manufacturing capabilities for hydroxyl PEG and related products. We offer a variety of hydroxyl PEG derivatives with different PEG chain lengths and linkage groups to meet specific customer needs. Our manufacturing process is conducted under strict quality control standards to ensure the highest quality and purity of our products. We also provide technical support and expertise to help customers with hydroxyl PEG applications.


  1. Lu, C. et al. Hydroxyl-PEG-phosphonic acid-stabilized superparamagnetic manganese oxide-doped iron oxide nanoparticles with synergistic effects for dual-mode MR imaging. Langmuir. 2019, 35(29): 9474-9482.

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PEGylation of Peptides and Proteins

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