Small-molecule Group Protected PEG

Small-molecule group protected PEG is a compound that is modified by binding a small molecule group to a polyethylene glycol molecule. The modification process involves attaching specific small molecule groups (e.g., Fmoc, Boc, etc.) to specific reaction sites on the PEG molecule to protect the PEG group. BOC Sciences offers a broad range of functionalized small-molecule protected PEG molecules, which allow the introduction of a variety of other groups, such as tert-butyl esters, propionic acids, azides, aldehydes, and others, at specific sites on the PEG.

Types of Small Molecule Group Protected PEGs

Boc-protected PEG

Boc-protected PEG molecules are PEG molecules modified by introducing tert-butoxycarbonyl (Boc) as a protecting group. We offer Boc-protected PEG molecules including t-Boc-N-amido-PEG16-alcohol, t-Boc-N-amido-PEG15-azide, t-Boc-N-amido-PEG20-propionic acid, and others.

Fmoc-protected PEG

The Fmoc (9-fluorenylmethoxycarbonyl) protecting group is a commonly used protecting group, mainly used in amino acid and peptide synthesis. However, in PEG modification, Fmoc groups can also be introduced for the protection of PEG molecules. We provide Fmoc-protected PEG molecules including Fmoc-N-amido-PEG10-propionic acid, Fmoc-PEG4-NHS ester, Fmoc-N-amido-PEG6-amine, etc.

Preparation of Small-molecule Group Protected PEG

The introduction of protecting groups requires the identification of the target reaction site of the PEG molecule, and then the introduction of small molecule protecting groups, such as benzyl (Bn), tert-butoxycarbonyl (Boc), and so on. We currently offer a wide range of small molecule protecting groups for PEG that can be used in your project development in the biopharmaceutical industry.

How to use Small-molecule Group Protected PEG?

The use of small molecule protecting groups PEG needs to be considered depending on the type of protecting group and the area of application. Generally, customers need to choose appropriate methods, such as acid hydrolysis, reductant reduction, enzyme catalysis, etc., when utilizing small molecule protecting group PEG. After removing the protective groups, bare target reaction sites are obtained, which can be subsequently modified and functionalized.

Advantages of Small-molecule Group Protected PEG

Selective Modification

Small-molecule group protected PEG enables selective modification of specific reaction sites. By introducing a protecting group, some of the reactive sites on the PEG molecule can be shielded, allowing the modification reaction to take place only at the target site. This allows control of the location and extent of modification and enables precise functionalization of the PEG molecule.

Reaction Protection

During PEG modification, some reactions may lead to non-specific side reactions or the formation of by-products. By introducing small molecule moiety protection, the reaction sites of PEG can be protected against unintended reactions during the modification process.

Controlled Release

Protective groups can be selectively removed when needed, exposing the active site of the modifier. This enables controlled release of the modifier, which is important for applications such as drug delivery and controlled release systems.

Enhanced Stability

Small-molecule group protected PEG can provide additional chemical stability and protect the modifier from environmental factors. This is important for applications in living organisms or other harsh conditions to extend the lifetime of the modifier and improve its performance.

Applications of Small-molecule Group Protected PEG


Functionalized small-molecule group protected PEG enables the covalent binding of PEG to other biologically active substances.

Chemical Synthesis

Small-molecule group protected PEGs play an important role in organic synthesis by regulating the solubility, reactivity, and chemical stability of PEG.


Small-molecule group protected PEG is used to immobilize biorecognition elements of biosensors, such as antibodies, DNA probes, etc., to achieve highly sensitive and selective biorecognition.

BOC Sciences plays a vital role in providing group protected PEG to support cutting-edge research and development in the biotechnology and pharmaceutical industries, so please contact us if you are interested in our products.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality



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BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

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