Aldehyde-PEG-Aldehyde

Synonyms: Aldehyde-polyethylene glycol-aldehyde; ALD-PEG-ALD

Aldehyde polyethylene glycol aldehyde (ALD-PEG-ALD) is a linear bifunctional peg reagent with two aldehyde (ALD) groups. It is usually a viscous liquid or solid powder, depending on the molecular weight. It can be stored for a long time at -20℃. ALD-PEG-ALD is a bifunctional PEG propionaldehyde for crosslinking two substrate molecules through a PEG spacer. Aldehyde reacts with amine and N-terminal of peptide and protein to form an imine containing a C=N double bond, which can be further reduced to a more stable C-N bond. PEG aldehyde or ketone derivatives can be used in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrazone linkage.