Boc-NH-PEG-NHS

Boc-NH-PEG-NHS is a linear heterobifunctional PEG reagent containing an NHS-ester and a Boc protected amine. It is a crosslinker with a PEG spacer group. Protected amines can be regenerated through weakly acidic conditions, such as TFA or dilute HCl. Boc-NH-PEG-NHS can be used to modify proteins, peptides and other materials by amino or other acid-reactive chemical groups. The BOC group can be de-protected under acidic conditions to release free amines for further reaction. NHS is a good leaving group and can act with the amine containing part. Boc-NH-PEG-NHS can be easily incorporated into liposomes and other nanoparticles through the NHS-amine reaction. Polyethylene glycolation increases solubility and stability and reduces the immunogenicity of peptides and proteins. It also inhibits nonspecific binding of charged molecules to the modified surface.