Cat. No. Product Name CAS No.
BPG-2773 Boc-NH-PEG-NHS, MW 1k-4k Inquiry

Boc-NH-PEG-NHS is a linear heterobifunctional PEG reagent containing an NHS-ester and a Boc protected amine. It is a crosslinker with a PEG spacer group. Protected amines can be regenerated through weakly acidic conditions, such as TFA or dilute HCl. Boc-NH-PEG-NHS can be used to modify proteins, peptides and other materials by amino or other acid-reactive chemical groups. The BOC group can be de-protected under acidic conditions to release free amines for further reaction. NHS is a good leaving group and can act with the amine containing part. Boc-NH-PEG-NHS can be easily incorporated into liposomes and other nanoparticles through the NHS-amine reaction. Polyethylene glycolation increases solubility and stability and reduces the immunogenicity of peptides and proteins. It also inhibits nonspecific binding of charged molecules to the modified surface.

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PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

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PEG linkers For Drug

Improved Circulation Half-Life

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