mPEG Phospholipids

mPEG-phospholipids are amphiphilic PEG or surfactant PEG. mPEG-phospholipids can be used to form invisible liposomes or micelles for targeted drug delivery and enhanced drug solubility. BOC Sciences offers a wide range of mPEG-phospholipids equipped with a number of different functional groups, which maintain their original properties while imparting additional properties for use in a wider range of applications.

Fig. 1. Schematic diagram of DSPE-mPEG content in targeted liposomes (PloS one. 2012, 7(10): e48515).

Types of mPEG Phospholipids

DOPE-PEG

DOPE-PEG is a complex consisting of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) and polyethylene glycol (PEG) groups. DOPE-PEG plays an important role in the preparation of nano-delivery systems by improving the stability of nanoparticles and drug encapsulation efficiency. We offer DOPE-PEG-NH2 ammonium salt, DOPE-PEG-COOH sodium salt, DOPE PEG(2000)-N-Cy5, and more.

DSPE-PEG

DSPE-PEG consists of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE) and a PEG group. As a phospholipid, DSPE can form lipid bilayers for the preparation of nanodelivery systems such as liposomes and nanomicelles. By introducing different functional groups, such as targeting ligands or fluorescent dyes, into the DSPE-PEG structure, nanoparticles can be endowed with specific properties and functions. We offer DSPE PEG(2000)-N-Cy5, DSPE-PEG(2000) Carboxy NHS, and others.

How to Functionalize mPEG Phospholipids?

Cross-linking Reaction

mPEG Phospholipids can be reacted with specific groups by activating esterification reagents to cross-link the material and enhance its mechanical properties and stability. At the same time, additional functional groups are provided for the modification of other molecules or the attachment of drugs. Types of molecules crosslinked with mPEG phospholipids can include proteins, peptides, phospholipids, polymers, etc.

Click Chemistry Reactions

Commonly used click chemistry reactions include alkyne-azide reactions and alkyne-alkyne olefin cycloadditions. By introducing alkyne functional groups into mPEG phospholipid molecules, they can be used to prepare mPEG phospholipid derivatives with specific properties and functions for drug delivery, biomedical research, and other applications.

Chemical Modification

Chemical modification of mPEG phospholipids can be done by hydroxylation modification, amination modification, esterification modification, phosphorylation modification, etc. to obtain targeted functionalized mPEG phospholipid molecules. Before chemical modification, it is necessary to ensure that the selected reaction is compatible with the structure and stability of the mPEG phospholipids and does not disrupt the function of the phospholipids under the reaction conditions.

Biocoupling Reactions

Biologically active molecules (e.g., antibodies, peptides, or nucleic acids) can be used to couple with specific functional groups on mPEG phospholipids to confer specific biological activity or targeting properties to the mPEG phospholipids.

Applications of mPEG Phospholipids

Cell Membrane Mimicry

mPEG phospholipids can form a bilayer structure similar to cell membranes, which is used to study the properties and interactions of cell membranes. Such structures can be used to construct artificial cell models, drug screening, and biosensors, among other applications.

Bioimaging

mPEG phospholipid nanoparticles can be used as probes for bioimaging. By labeling mPEG phospholipid nanoparticles with fluorescent dyes or radioisotopes, imaging of specific tissues or organs, such as tumor imaging and biomolecule tracking, can be achieved.

Tissue Repair

The mPEG phospholipid nanoparticles can encapsulate growth factors such as osteoblast growth factor (BMP) and vascular endothelial growth factor (VEGF). These growth factors play an important role in tissue repair by promoting processes such as angiogenesis, cell proliferation, and bone tissue regeneration. mPEG phospholipids as carriers can protect the growth factors from degradation and control their release rate, thus improving the stability and effectiveness of the growth factors.

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Reference

1. Tanifum, E. A. et al. Intravenous delivery of targeted liposomes to amyloid-β pathology in APP/PSEN1 transgenic mice. PloS one. 2012, 7(10): e48515.