Inquiry

PEGylation of Nanocarriers

Nanocarriers, such as micelles, liposomes, polymeric nanoparticles and inorganic nanoparticles are promising tools for controlled drug delivery or imaging in cancer therapy and many other applications. Up to date, a number of nanocarriers have been approved for clinical treatment of a variety of therapeutics. Our enormous knowledge, advanced skills and excellent capabilities will provide you with the most optimized synthesis route, the PEGylated products with the best quality, and offer you a value-added service to meet development needs.

Fig. 1 Schematic representation of different nanocarriers with the PEG-exposed surface. (<em>Journal of controlled release </em><strong>2014</strong>, 192, 67-81)Fig. 1 Schematic representation of different nanocarriers with the PEG-exposed surface. (Journal of controlled release 2014, 192, 67-81)

Our services include but not limited as following:

PEGylation of Polymeric Nanoparticles

Fig.2 Schematic diagram of formation of PEGylated lecithin-chitosan nanoparticle. (<em>AAPS PharmSciTech </em><strong>2020,</strong> <em>21</em> (7), 285)Fig.2 Schematic diagram of formation of PEGylated lecithin-chitosan nanoparticle. (AAPS PharmSciTech 2020, 21 (7), 285)

Biodegradable polymeric nanoparticles have many advantages for drug delivery, such as controlled release and targeting. However, after intravenous administration of polymeric nanoparticles, they will be cleared by the endothelial reticulum system within a few seconds or minutes. In order to overcome this shortcoming, hydrophilic PEG is introduced to modify the polymer. The introduction of PEG will not only affect the biodegradation behavior of nanoparticles, but also affect the release and distribution of drugs in the body. Polymeric nanoparticles are usually PEGylated by (1) physical surface coverage with PEG or PEG derivatives, (2) preparation of nanoparticles with PEG block co-polymers and (3) grafting PEG onto the nanoparticles surface.

PEGylation of Inorganic Nanoparticles

Fig.3 Schematic illustration of the function of PEG to prevent uptake by the reticuloendothelial system. (<em>Nanomedicine</em> <strong>2011</strong>, 6 (4), 715-728.)Fig.3 Schematic illustration of the function of PEG to prevent uptake by the reticuloendothelial system. (Nanomedicine 2011, 6 (4), 715-728.)

Inorganic nanoparticles made of calcium phosphate, gold, silica and iron oxide are preferred for drug delivery due to ease of preparation and uniform size and amenability for surface functionalization. However, these are less stable and could be toxic in biological systems. Therefore, in order to improve the biological stability and biocompatibility, surface modification has been carried out with PEG.

PEGylation of Liposomes

Fig.4 Schematic diagram of PEGylated liposome.Fig.4 Schematic diagram of PEGylated liposome.

Liposome is an ideal drug delivery carrier. It has targeted properties, longer blood retention time and higher organ distribution selectivity, can improve the efficacy of drugs and reduce toxic side effects. Ordinary liposomes have the disadvantage of being easily cleared from the systemic circulation by liver and spleen macrophages. In this case, PEGylation can solve the above shortcomings, making liposomes stay in the blood for a longer time and increasing the passive targeting function of drugs. Moreover, it is simple to prepare PEG-phospholipid derivatives in advance, which has become the current research focus of PEGylation technique.

PEGylation of Micelles

Fig.5 Schematic representation of the micelle formation using heterobifunctional PEG and PEG derivatives. (<em>Advanced drug delivery reviews </em><strong>2003,</strong> <em>55</em> (3), 403-419)Fig.5 Schematic representation of the micelle formation using heterobifunctional PEG and PEG derivatives. (Advanced drug delivery reviews 2003, 55 (3), 403-419)

Micelles are frequently preferred choice for anticancer drug delivery. Preparation of PEGylated micelles mostly utilizes PEGylated polymers or lipids through synthetic approaches. Block copolymer micelles with PEG coronas have emerged as systems with great potential in drug delivery, as they combine biocompatibility with the synthetic versatility of PEG. A variety of activated PEGs can be used exploited for these systems, such as block copolymer structures, providing control over the type and stability of covalent. linkage formed.

Why Us?

Advantages

PEGylation Service Process

PEGylation Service Process

Reference

  1. Kolate, A.; Baradia, D.; et al. PEG - a versatile conjugating ligand for drugs and drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society 2014, 192, 67-81.
  2. Howard, M. D.; Jay, M.; et al. PEGylation of nanocarrier drug delivery systems: state of the art. Journal of Biomedical Nanotechnology 2008, 4 (2), 133-148.
  3. Jokerst, J. V.; Lobovkina, T.; Zare, R. N.; Gambhir, S. S., Nanoparticle PEGylation for imaging and therapy. Nanomedicine 2011, 6 (4), 715-728.
  4. Otsuka, H.; Nagasaki, Y.; Kataoka, K., PEGylated nanoparticles for biological and pharmaceutical applications. Advanced drug delivery reviews 2003, 55 (3), 403-419.
  5. Mahmood, S.; Kiong, K. C.; et al. PEGylated Lipid Polymeric Nanoparticle–Encapsulated Acyclovir for In Vitro Controlled Release and Ex Vivo Gut Sac Permeation. AAPS PharmSciTech 2020, 21 (7), 285.

Why BOC Sciences?

  • Large Stock

    More than 2000+ products in inventory

  • Global Delivery

    Warehouses in multiple cities to ensure fast delivery

  • mg to kg

    Multi specification for academic research and industrial production

  • 24/7 Technical Support

    Strict process parameter control to ensure product quality

Products

Resources

Our Feature

BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

  • Our Feature icon1
  • Our Feature icon2
  • Our Feature icon3
  • Our Feature icon4
PEGylation of Peptides and Proteins

PEGylation of Peptides
and Proteins

Reduce the Immunogenicity of Peptide/Protein Drugs

Learn More

APPLICATIONS

APPLICATIONS

PEG linkers For Drug

Improved Circulation Half-Life

Learn More

Have Customer Reviewed On Us?

logo

Chat With Us

Online Inquiry

Verification code

Copyright © 2024 BOC Sciences. All rights reserved.