mPEG-Alkene

Synonyms: Methoxy-PEG-Alkene; Methoxy polyethylene glycol-Alkene

Methoxy polyethylene glycol Alkene (mPEG-Alkene) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-CH=CH2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised mPEG-Alkene lipids and phospholipids can be used for protein-PEG conjugation. It is commonly used in drug delivery, new nanomaterial research, polymer synthesis, organic synthesis, targeted drug application, and sustained and controlled release of drugs.