Fmoc-NH-PEG-NH2

Fmoc-NH-PEG-NH2 is a linear heterobifunctional PEG reagent with Fmoc protected amine and a free amine. It is a useful crosslinking reagent with a PEG spacer. Free amines are usually in the form of TFA or HCl salts and can be used to react with carboxylic acid esters or NHS esters. Protected amines can be regenerated by mild alkaline conditions. Fmoc-NH-PEG-NH2 can modify proteins, peptides and other materials by amino groups. PEGylation increases solubility and stability and reduces the immunogenicity of peptides and proteins. It also inhibits the non-specific binding of charged molecules to the modified surface.