As an amphiphilic polymer, PEG can be soluble in water and most organic solvents, and has the characteristics of good biocompatibility, non-toxicity, and low immunogenicity. It can be wildly applied in bio-medical industry, chemical synthesis, cosmetics, textile industry, plastic industry and others.
PEGylation is defined as the covalent attachment of poly(ethylene glycol) (PEG) chains to bioactive substances, such as nanoparticles, proteins, peptides or non-peptide molecules. This technology emerged gradually with progress in field of biologicals and polymer chemistry and was exploited to...
PEG for Drug Delivery
The majority of small molecule drugs, proteins and peptides, as well as liposomal and micellar nanocarriers on the market or in advanced clinical trials are PEGylated products, i.e. PEGylation.
PEG for Pharmaceutical Preparation
PEG is a commonly used as pharmaceutical excipient, which has been widely applied in various medicaments such as soft ointment, suppository, drop pill, hard capsule, eye drop, injection and tablet.
PEG for Cosmetic Application
PEG and PEG derivatives are widely used as humectants, solvents, binders, emulsion stabilizers, and viscosity increasing agents in a wide variety of personal care products.
PEG for Imaging Diagnosis
PEG is a coiled polymer of repeating ethylene ether units with dynamic conformations. In both imaging and drug delivery applications, chemical modification using PEG polymers can reduce RES uptake and prolong the circulation time.