Small-molecule Homobifunctional PEG
Cat. No. | Product Name | CAS No. | |
---|---|---|---|
BPG-2458 | THP-PEG11-THP | Inquiry | |
BPG-2459 | Bis-PEG5-PFP ester | 1334177-78-4 | Inquiry |
BPG-2461 | Mal-NH-PEG7-NH-Mal | Inquiry | |
BPG-2464 | Bis-PEG10-t-butyl ester | Inquiry | |
BPG-2476 | Azido-PEG14-azide | Inquiry | |
BPG-2480 | Bis-PEG13-acid | 2225903-66-0 | Inquiry |
BPG-2495 | THP-PEG12-THP | Inquiry | |
BPG-2499 | Amino-PEG15-amine | Inquiry | |
BPG-2500 | Nonaethylene glycol di(p-toluenesulfonate) | 109635-64-5 | Inquiry |
BPG-2522 | Bis-PEG7-PFP ester | 1334170-01-2 | Inquiry |
BPG-2571 | Mal-NH-PEG11-NH-Mal | Inquiry | |
BPG-2578 | Bis-PEG17-acid | 2226897-74-9 | Inquiry |
BPG-2583 | NHS-PEG12-NHS | Inquiry | |
BPG-2585 | THP-PEG16-THP | Inquiry | |
BPG-2616 | NHS-PEG16-NHS | Inquiry | |
BPG-2618 | Amino-PEG23-amine | Inquiry | |
BPG-2648 | Mal-NH-PEG19-NH-Mal | Inquiry | |
BPG-3576 | 4,7,10,13,16,19,22,25,28,31,34-Undecaoxaheptatriaconta-1,36-diyne | 1351373-48-2 | Inquiry |
BPG-4563 | PEG2-bis(phosphonic acid) | 116604-42-3 | Inquiry |
BPG-4564 | TCO-PEG12-TCO | Inquiry |
BOC Sciences offers a wide range of small-molecule homobifunctional PEG products. The functional groups can be amines, thiols, carboxyls, aldehydes, etc., depending on the application you need. Small-molecule homobifunctional PEG refers to a compound that combines two identical small molecules with a polyethylene glycol molecule. The two homobifunctional groups of the PEG molecule allow researchers to react with other molecules or surfaces in specific chemical reactions.
Types of Small-molecule Homobifunctional PEG
HO-PEG-OH
This type of PEG molecule has hydroxyl (-OH) functional groups at both endpoints. Homobifunctional PEGs are commonly used to react with other compounds or surfaces to form interactions such as covalent or hydrogen bonds.
NH2-PEG-NH2
NH2-PEG-NH2 is commonly used to react with acid groups or other functional groups to form amination or coupling reactions. We offer Amino-PEG11-amine, Amino-PEG9-amine, Amino-PEG8-amine, Amino-PEG7-amine and others.
SH-PEG-SH
Dithiol-based PEG is commonly used to react with other thiol compounds to form disulfide bonds or interpenetrating cross-linking reactions.
CHO-PEG-CHO
Diels-Alder PEG is commonly used to react with functional groups such as amine or sulfhydryl groups to form aldolization or sulfhydrylation reactions.
Preparation of Small-molecule Homobifunctional PEGs
PEG Screening
According to the characteristics of the target molecule to be prepared, PEG molecules with suitable molecular weight and active terminal groups are selected.
Functional Group Introduction
Introduce the target small molecule functional groups into PEG, which can be amine groups, thiol groups, etc.
Chemical Reaction
A first small molecule compound with a reactive group is added to the dissolved PEG. After a period of reaction, a second small molecule compound having a reactive group is added. After completion of the reaction, the product is extracted and purified from the reaction mixture by appropriate purification methods (e.g., solvent extraction, washing, distillation, etc.).
Purification and Characterization
The prepared small-molecule homobifunctional PEG is purified by appropriate purification methods, and the product is then characterized using appropriate analytical techniques to ensure its structure and purity.
Optimization of Small-molecule Homobifunctional PEG
Optimization of Reaction Conditions
Systematic adjustment of the reaction temperature and reaction time allows for the determination of optimal reaction conditions. The optimal molar ratio between reactants is then determined to keep the reaction at the most efficient stoichiometric ratio.
Catalyst Optimization
According to the type of reaction and the characteristics of the functional groups, suitable catalysts are selected, such as acidic catalysts, basic catalysts, or metal catalysts.
Optimization of Purification Method
Select the most suitable purification method, such as column chromatography, counter-current chromatography, freeze-drying, etc., to remove impurities and unreacted substances and to obtain products of high purity.
Functions of Small-molecule Homobifunctional PEGs
Bioconjugation
Small-molecule homobifunctional PEG can be used to link biomolecules (e.g. proteins, antibodies, peptides, etc.) to other molecules or surfaces.
Surface Modification
Small-molecule homobifunctional PEG can be used to modify the surface of materials to change their properties and functions.
Bioactivity Modulation
The interaction and activity of PEG with biomolecules can be modulated by introducing specific functional groups on the PEG molecule.
Derivatives of PEG have very excellent properties and can play an important role in a variety of fields. BOC Sciences provides customers with high-quality homobifunctional PEG based on specialized knowledge and experience, as well as technical support for these products. If you are interested in our products, please feel free to contact us.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- How to Perform Polyethylene Glycol (PEG) Modification?
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Polyethylene Glycol (PEG) Modifier Selection Guide
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Cholesterol: Definition, Structure, Synthesis, Types and Functions
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- FDA-Approved Antibody-Drug Conjugates up to 2024
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Ionizable Lipids for RNA Delivery
- Lipid Classification and Drug Delivery Systems
- Lipid Formulations: Key Absorption-Enhancing Technologies in New Drug Development
- Lipid-Drug Conjugates (LDCs) for Nanoparticle Drug Delivery
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated Drugs: Definition, Structure, Classification and Benefits
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Pharmacokinetics and Bioanalysis of PEGylated Drugs
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- Vaccines: Definition, History, Ingredients, Types and Mechanism of Action
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipid-Drug Conjugates (LDCs)?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are PEG Lipids?
- What are Phospholipids?
- What are Sterols? - Definition, Structure, Function, Examples and Uses
- What is Biotinylation and Biotinylated PEG?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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