FA-PEG-(γ)PGA

Folate-polyethylene glycol (peg)-poly-L-glutamic acid (FA-PEG–(γ)PGA) is a linear amphiphilic block copolymer with poly-glutamic acid as hydrophobic part and azide functionalized PEG as hydrophilic part. FA-PEG–(γ)PGA can self-assemble into micelles. Folic acid on PEG chain has high affinity to folate receptors, which can be used to target cell membrane receptors for drug delivery. Folate receptor protein, which is over expressed by a number of tumor cells. It is a solid or semisolid which depends on its molecular weight. The bigger the molecular weight, the more likely it is to be a solid.