Boc-NH-PEG-Succinimidyl propionate

Synonyms: Boc-NH-PEG-SPA

Boc-NH-PEG-Succinimidyl propionate is a PEG derivative of heterofunctional group, with Boc protected amines and succinimidyl propionate groups at both ends of the molecular chain. Protected amines can be regenerated through weakly acidic conditions, such as TFA or dilute HCl. The Boc group can be de-protected under acidic conditions to release free amines for further reaction. Boc-NH-PEG-Succinimidyl propionate can be used to modify proteins, peptides and other materials by amino or other acid-reactive chemical groups. Polyethylene glycolation increases solubility and stability and reduces the immunogenicity of peptides and proteins. It also inhibits nonspecific binding of charged molecules to the modified surface.