Azide PEG, Azido PEG(-N3)

Azide/Azido PEG(-N3) is a bifunctional PEG derivative that can be used to modify proteins, peptides and other materials. The azido group reacts with alkynes in aqueous solution catalyzed by copper. It is also readily reduced to an amine group, while the other functional group can react with other molecules or functional groups. PEGylation increases the solubility and stability of peptides and proteins and reduces immunogenicity. It can also inhibit non-specific binding of charged molecules to modified surfaces. BOC Sciences has different types of azide PEG products available through custom synthesis.

Synthesis of polyethylene glycol (PEG)-branch-azide bivalent-brush polymersFig. 1. Synthesis of polyethylene glycol (PEG)-branch-azide bivalent-brush polymers (Journal of the American Chemical Society, 2011, 133(3): 559-566).

Examples of Azide PEG, Azido PEG(-N3)


Amine-PEG-azide is a very commonly used bifunctional crosslinker. The amino group reacts with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes). The azide group can be reacted with alkynes, BCN, DBCO via click chemistry to produce stable triazole bonds.


Azido-PEG-NHS is an amine-reactive compound having the ends of the Azido and NHS ester molecular chains, respectively. It can be used to modify primary amine groups with azide groups (e.g., side chains of lysine residues or aminosilane-coated surfaces) via stabilized amide bonds.


Biotin-PEG-Azide are non-cleavable azide biotinylation reagents that react with terminal alkynes via copper-catalyzed click reactions, with strained cyclooctyl groups (e.g., DBCO or BCN compounds) via copper-free click reactions or with phosphine-labeled molecules via a mechanism known as Staudinger chemistry, enabling efficient and specific derivatization molecules in biological samples coupling.

Azide PEG Thiol

Azido PEG thiols (N3-PEG-SH), also known as azido PEG thiols, are one of Nanocs' thiolated click chemistry PEG derivatives. Catalyzed by copper ions, the azide reacts efficiently with alkynes in aqueous solution. The 1,3-dipole cycloaddition between the alkyne and the azide is a high-yield click chemistry reaction that efficiently bonds the two corresponding molecules together. Due to the strong binding affinity between thiols and precious metal surfaces, they can also be used for the modification of gold particles or films. PEG linkers between azides and thiols provide better water solubility, flexible linker structures and enhanced stability.

Advantages of Azide PEG, Azido PEG(-N3)

  • Versatile Bioconjugation: Azide/Azido PEGs enable efficient and selective bioconjugation reactions through click chemistry. The azide group can be reacted with a variety of functional groups (e.g., alkynes or strained olefins) using CuAAC or SPAAC reactions. This versatility allows azide/azido PEGs to be conjugated to a variety of biomolecules, nanoparticles or surfaces.
  • Bio-Orthogonal Reactions: Click chemistry reactions involving azide/azido PEGs are bio-orthogonal, meaning that they can be carried out in the presence of biological systems without interfering with their normal function. This property is critical for applications such as in vivo imaging, targeted drug delivery and studying biological processes.
  • High Reaction Efficiency: Azide/Azido PEG click chemistry typically exhibits high reaction efficiency and selectivity. Copper-catalyzed azide-alkyne cycloadditions and strain-promoted azide-alkyne cycloadditions are known for their fast kinetics and compatibility with a wide range of reaction conditions.

As a trusted supplier of Azide/Azido PEG, BOC Sciences is committed to providing high-quality products and customized solutions to meet the evolving needs of researchers and industry professionals. If you have a need for our products, please feel free to contact us.


  1. Johnson, J.A. et al. Core-clickable PEG-branch-azide bivalent-bottle-brush polymers by ROMP: grafting-through and clicking-to. Journal of the American Chemical Society. 2011, 133(3): 559-566.

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PEGylation of Peptides and Proteins

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