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Glycolithocholic acid-[2,2,4,4-d4]

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Catalog NO.	BPG-3236
Product Name	Glycolithocholic acid-[2,2,4,4-d4]
CAS	2044276-16-4
Molecular Formula	C26H39D4NO4
Molecular Weight	437.65

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Description	Glycolithocholic acid-[2,2,4,4-d4] is the labelled analogue of Glycolithocholic acid. Glycolithocholic acid is a bile acid-glycine conjugate that can inhibits sialyltransferase.
Synonyms	Glycolithocholic acid-2,2,4,4-d4; Glycolithocholic-2,2,4,4-d4 Acid; N-(3α-Hydroxy-24-oxocholan-24-yl)glycine-d4; 3α-Hydroxy-5β-cholanoic Acid N-(Carboxymethyl)amide-d4
IUPAC Name	((R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl-2,2,4,4-d4)pentanoyl)glycine
Canonical SMILES	CC(CCC(=O)NCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
InChI	InChI=1S/C26H43NO4/c1-16(4-9-23(29)27-15-24(30)31)20-7-8-21-19-6-5-17-14-18(28)10-12-25(17,2)22(19)11-13-26(20,21)3/h16-22,28H,4-15H2,1-3H3,(H,27,29)(H,30,31)/t16-,17-,18-,19+,20-,21+,22+,25+,26-/m1/s1/i10D2,14D2
InChIKey	XBSQTYHEGZTYJE-CPHZDNHJSA-N
Purity	≥ 98% (CP); 98% atom D
Solubility	Soluble in methanol (100 μg/mL)
Related CAS	474-74-8 (unlabelled)
Shelf Life	1 Year
Storage	-20°C
Exact Mass	437.34
Hygroscopic	No
Light Sensitive	No
Percent Composition	C 71.35%, H 10.82%, N 3.20%, O 14.62%

Glycolithocholic acid-[2,2,4,4-d4], a deuterated bile acid utilized in diverse biochemical and clinical research applications, offers intriguing possibilities in scientific exploration. Here are four key applications of Glycolithocholic acid-[2,2,4,4-d4] presented with high perplexity and burstiness:

Lipid Metabolism Studies: Acting as an isotope-labeled standard in lipid metabolism research, Glycolithocholic acid-[2,2,4,4-d4] enables researchers to trace intricate bile acid pathways and interconnections within the physiological framework. This fundamental understanding sheds light on metabolic anomalies such as cholestasis and non-alcoholic fatty liver disease, unveiling deeper insights into systemic functions.

Pharmacokinetics: In the realm of pharmacokinetic investigations, this deuterated bile acid emerges as a pivotal instrument for deciphering the absorption, distribution, metabolism, and excretion dynamics of bile acids. By facilitating precise quantification in biological specimens through mass spectrometry, it plays a crucial role in drug development and safety evaluations. Insights into pharmacokinetic parameters gleaned from these studies guide the development of more efficacious and safer therapeutic interventions.

Biomarker Identification: Within the domain of clinical research, Glycolithocholic acid-[2,2,4,4-d4] emerges as a potent tool for the identification and quantification of biomarkers associated with hepatic and gastrointestinal disorders. Through targeted metabolomics approaches, researchers can discern aberrant bile acid profiles linked to specific health conditions. This knowledge holds the promise of early disease detection, enhanced disease monitoring, and tailored treatment modalities, fostering personalized healthcare strategies.

Stable Isotope Dilution Assays: In the realm of biochemical assays, Glycolithocholic acid-[2,2,4,4-d4] assumes a critical role as an internal standard for stable isotope dilution analyses. This analytical technique enhances the accuracy and precision of quantitative measurements by compensating for sample variability and loss. Such meticulous assays are indispensable for rigorous scientific investigations and quality assurance practices across diverse industries.

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