With years of experience in biotechnology services, BOC Sciences offers customized PEGylation services for a variety of applications to meet your specific needs.
PEGylation is the process that the polymer chains of polyethylene glycol (PEG) are attached to molecules and macrostructures (such as drugs, therapeutic proteins or vesicles) in a covalent or non-covalent way. PEGylation is routinely achieved by incubating the reactive derivatives of PEG with the target molecules. Protein and polypeptide drugs are easily eliminated by metabolism after entering the body, thereby reducing the effective concentration. Small molecule drugs also have trouble in fusion with cells, and also easily filtered by the glomerulus. PEGylation is the most established and best validated drug delivery strategy to overcome these common limits for therapeutic application of peptides, proteins, antibodies and small molecule drugs. By increasing molecular weight of molecules, or coverage of epitopes or blockage of sequences prone toenzymatic degradation, PEGylation can impart the unmodified form several significant pharmacological advantages:
Figure 1. Main advantages of PEGylated protein. (Veronese F. M., & Pasut G., 2005)
The PEGylation technology was first used in protein modification and then has been transferred to small molecule drugs. This leads to a new wave in pharmaceutical industry. Since the emergence of the first PEGylated drug, Adagen, in 1990, there have been more PEGylated drugs appear on the market. Many scientific studies are committed to PEGylate engineering and the clinical value of PEGylation is now well established.
BOC Sciences provides synthetic polymer PEG modification and bioconjugation services. We also offer purification services to ensure the high quality of the products in view of the fact that PEGylation of drugs is easy to form a mixture of various dispersions. With our expertise in the field of PEGylation and a first-class technical team, we can offer professional complete PEGylation method development services based on your specific needs in a timely and cost-effective manner. Our services include but not limited as following:
BOC Sciences' PEGylation services are tailored for each customer. If you are interested in our services or products, please feel free to contact us for more detailed information.
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