PEGylation Services
- PEGylation of Amino Acids
- PEGylation of Nanocarriers
- PEGylation of Peptides and Proteins
- PEGylation of Small Molecule Drugs
- PEGylation of Lipids
- PEGylation of Nucleic Acids
- PEGylation of Antibodies
- PEGylation of Carbohydrates
- PEGylation of Biotin
- PEGylation of Enzymes
- PEGylation of Cytokines
PEGylation is a chemical process to couple polyethylene glycol (PEG) polymer chains to macromolecules, such as proteins, drugs or vesicles. By increasing the volume of drug molecules, it can effectively extend its half-life in the body, while shielding its immune sites to significantly reduce immunogenicity. PEGylation is one of the most effective long-acting protein preparation technology recognized internationally. As a leading biotechnology services supplier, BOC Sciences has advanced skills that can offer customized synthesis pathways of various PEGylated conjugates, such as peptides/proteins, oligonucleotides, small molecule drugs, as well as different types of nanocarriers for customers to meet their unique requirements.
PEGylation services include:
In order to accomplish PEGylation, a variety of chemical modifications are utilized to prepare an active PEG derivative with a reactive functional group at one or both termini. Further the use of reactive functional group mainly depends on the substrate to be conjugated to PEG. Our PEGylation techniques can be roughly divided into the following three parts:
PEGylation of Peptides and Proteins
Among the 20 types of common amino acids that make up proteins, only those with polar side chain groups can be chemically modified. The activated PEG realizes the coupling through chemical reaction with the amino acid residues on the peptide or protein molecules. The active groups on these amino acid residues are mostly nucleophilic, and their activity usually decreases in the following order: sulfhydryl > α-amino > ɛ-amino > carboxy > hydroxyl. With our expertise as a leader in the field of PEGylation, BOC Sciences can offer you great services to help you design desired PEGylated proteins
The addition of PEG to the nanocarrier surface can reduce many of challenges, such as reducing reticuloendothelial system (RES) uptake and increasing circulation time versus uncoated counterparts. Due to difference in the chemical make-up, strategies used for PEGylation of nanocarriers can be broadly classified under the titles of polymeric nanoparticles, liposomes, micelles and inorganic nanoparticles. Our expertise in polymer chemistry and surface science can provide you practice advices, help you design the experiment, and prepare PEG functionalized products for your needs.
PEGylation of Small Molecule Drugs
To date, many organic small molecule drugs have gradually adopted PEGylation technology and certain progress has been made. The conjugated drugs also has good biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly excreted from the body without any toxic side effects. Pease contact us for more details of our preclinical PEGylation service. BOC Sciences's dedicated and experienced PEGylation group will offer you the most optimal solution for your project.
PEGylation Service Model 1
PEGylation service model 2
Why Us?
PEGylation Service Process
Reference
- Harris, J. M.; Chess, R. B., Effect of PEGylation on pharmaceuticals. Nature reviews Drug discovery 2003, 2 (3), 214-221.
- Kolate, A.; Baradia, D.; et al. PEG - a versatile conjugating ligand for drugs and drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society 2014, 192, 67-81.
- Pasut, G.; Veronese, F. M., State of the art in PEGylation: the great versatility achieved after forty years of research. Journal of controlled release : official journal of the Controlled Release Society 2012, 161 (2), 461-72.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DNP PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Folate PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- SPDP PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEG Purification Techniques of Plasmid DNA
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
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Industry News
- Applications of PEG-DSPE: Drug Carriers and Drug Delivery
- Applications of Polyethylene Glycol (PEG) as Medical Devices
- Classification of Lipid-Based Vaccine Adjuvants
- FDA approved PEGylated Products
- How are Liposomes Different from Micelles?
- How Lipid Nanoparticles (LNPs) Deliver RNA Drugs?
- Hyaluronic Acid & PEGylated Hyaluronic Acid
- Lipid Classification and Drug Delivery Systems
- Liposome in Drug Delivery
- Overview of Liposome Preparation Process
- PEG in Pharmaceutical Preparations (I): Solvents, Lubricants, Adhesives and More
- PEG in Pharmaceutical Preparations (II): Stabilizers, Plasticizers and Modification Materials
- PEG Linkers in Antibody Drug Conjugates and PROTACs
- PEG-DSPE Block Copolymers and Their Derivatives
- PEGylated RGD Peptides: A Promising Tool for Targeted Drug Delivery
- Polyethylene Glycol (PEG) Modified Targeting Nanomaterials
- Preparation Method of PEG Hydrogel
- The PROTAC Technology in Drug Development
- What are Biotinylation and Biotinylated PEG?
- What are Lipid Excipients and Their Applications?
- What are Lipid Nanoparticles and Their Applications?
- What are Lipids?
- What are Monodispersed and Polydispersed PEGs?
- What are Phospholipids?
- What is Click Chemistry?
- What is Hydrogel?
- What is Methoxy Polyethylene Glycol (mPEG)?
- What is Nanogels and Its Applications?
- What is the Formulation of Lipid Nanoparticles (LNPs)?
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.
PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS
PEG linkers For Drug
Improved Circulation Half-Life
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