PEGylation is a chemical process to couple polyethylene glycol (PEG) polymer chains to macromolecules, such as proteins, drugs or vesicles. By increasing the volume of drug molecules, it can effectively extend its half-life in the body, while shielding its immune sites to significantly reduce immunogenicity. PEGylation is one of the most effective long-acting protein preparation technology recognized internationally. As a leading biotechnology services supplier, BOC Sciences has advanced skills that can offer customized synthesis pathways of various PEGylated conjugates, such as peptides/proteins, oligonucleotides, small molecule drugs, as well as different types of nanocarriers for customers to meet their unique requirements.
In order to accomplish PEGylation, a variety of chemical modifications are utilized to prepare an active PEG derivative with a reactive functional group at one or both termini. Further the use of reactive functional group mainly depends on the substrate to be conjugated to PEG. Our PEGylation techniques can be roughly divided into the following three parts:
Among the 20 types of common amino acids that make up proteins, only those with polar side chain groups can be chemically modified. The activated PEG realizes the coupling through chemical reaction with the amino acid residues on the peptide or protein molecules. The active groups on these amino acid residues are mostly nucleophilic, and their activity usually decreases in the following order: sulfhydryl > α-amino > ɛ-amino > carboxy > hydroxyl. With our expertise as a leader in the field of PEGylation, BOC Sciences can offer you great services to help you design desired PEGylated proteins
The addition of PEG to the nanocarrier surface can reduce many of challenges, such as reducing reticuloendothelial system (RES) uptake and increasing circulation time versus uncoated counterparts. Due to difference in the chemical make-up, strategies used for PEGylation of nanocarriers can be broadly classified under the titles of polymeric nanoparticles, liposomes, micelles and inorganic nanoparticles. Our expertise in polymer chemistry and surface science can provide you practice advices, help you design the experiment, and prepare PEG functionalized products for your needs.
To date, many organic small molecule drugs have gradually adopted PEGylation technology and certain progress has been made. The conjugated drugs also has good biocompatibility, can be dissolved in the tissue fluid in the body, and can be quickly excreted from the body without any toxic side effects. Pease contact us for more details of our preclinical PEGylation service. BOC Sciences’s dedicated and experienced PEGylation group will offer you the most optimal solution for your project.
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