4-Arm PEG-SG

Synonyms: Four-Arm polyethylene glycol-Succinimidyl Glutarate ester; Four-Arm PEG-SG; Four-Arm polyethylene glycol-SG

Four-Arm polyethylene glycol-Succinimidyl Glutarate ester (4-Arm PEG-SG) is a multiarm PEG derivative with succinimidyl NHS ester groups at each terminal of the four arms connected to one pentaerythritol core. It is usually a solid powder or particle, which needs to be protected by inert gas, frozen and dissolved in some organic reagents such as dimethyl sulfoxide and dimethylformamide. PEG-SG (succinimidyl glutarate ester) is one type of PEG-NHS reagents. There is a C3 hydrocarbon ester linkage between PEG and the NHS ester. Four arm polyethylene glycol derivatives have a variety of active groups that can be used to modify proteins, peptides and other materials through their functional groups. PEG modification can improve solubility and stability, and reduce immunogenicity of proteins and peptides. It can also inhibit the nonspecific binding of charged molecules on modified surfaces.