4-Arm PEG-SA

Synonyms: Four-Arm polyethylene glycol-Succinic Acid; Four-Arm PEG-SA; Four-Arm polyethylene glycol-SA

Four-Arm polyethylene glycol-Succinic Acid (4-Arm PEG-SA) is a multiarm PEG derivative with carboxylic acid groups at each terminal of the four arms connected to one pentaerythritol core. There is a C3 ester linkage between PEG and the succinic acid COOH group. It is usually a solid powder or particle, which needs to be protected by inert gas, frozen and dissolved in some organic reagents such as dimethyl sulfoxide and dimethylformamide. Four arm polyethylene glycol derivatives have a variety of active groups that can be used to modify proteins, peptides and other materials through their functional groups. PEG acid can be used to react with amine groups with peptide coupling reagents such as NHS and DCC, EDC.