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Azido-PEG7-NHS ester

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Category	Azido-PEGn-NHS ester
Catalog NO.	BPG-0869
Product Name	Azido-PEG7-NHS ester
Molecular Formula	C21H36N4O11
Molecular Weight	520.50

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Description	Azido-PEG7-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms	Azido-PEG7-CH2CO2-NHS; N3-PEG7-C2-NHS ester; N3-PEG7-CH2CH2COONHS Ester; 1-[(1-Azido-24-oxo-3,6,9,12,15,18,21-heptaoxatetracosan-24-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(24-azido-1-oxo-4,7,10,13,16,19,22-heptaoxatetracos-1-yl)oxy]-
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C21H36N4O11/c22-24-23-4-6-30-8-10-32-12-14-34-16-18-35-17-15-33-13-11-31-9-7-29-5-3-21(28)36-25-19(26)1-2-20(25)27/h1-18H2
InChIKey	UAIQKZXMCWWNND-UHFFFAOYSA-N
Purity	≥95%
Related CAS	1108750-59-9 (polymer)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

Azido-PEG7-NHS ester is a bifunctional reagent widely used in biochemical and pharmaceutical research for its ease of functionalization and bio-orthogonal properties. Here are some key applications of Azido-PEG7-NHS ester:

Bioconjugation: Azido-PEG7-NHS ester is commonly used for the conjugation of biomolecules such as proteins, peptides, and antibodies. The NHS ester reacts with amine groups, while the azido group enables click chemistry for further modifications. This facilitates the creation of bioconjugates for applications in diagnostic assays and therapeutic delivery.

Drug Delivery Systems: In drug delivery research, Azido-PEG7-NHS ester is used to functionalize nanoparticles and other carriers. By attaching therapeutic agents to these carriers via the azido group, researchers can achieve targeted drug delivery and controlled release. This helps in enhancing the efficacy and reducing the side effects of pharmaceutical treatments.

Surface Functionalization: Azido-PEG7-NHS ester is employed to modify surfaces of materials, making them bio-compatible and more suitable for cell culture studies. The peptide groups provide a transparent surface that cells can adhere to and explore. This makes it essential for developing implanted medical devices and tissue engineering scaffolds.

Bio-orthogonal Labeling: The compound's ability to undergo click chemistry makes it ideal for bio-orthogonal labeling in live-cell imaging. By attaching fluorescent tags or other probes to biomolecules using Azido-PEG7-NHS ester, researchers can visualize cellular processes in real time. This is instrumental in studying dynamic biological interactions and tracking molecular events.

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