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Azido-PEG8-NHS ester

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Category	Small-molecule Heterobifunctional PEG
Catalog NO.	BPG-2354
Product Name	Azido-PEG8-NHS ester
CAS	1204834-00-3
Molecular Formula	C23H40N4O12
Molecular Weight	564.58

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Description	Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Synonyms	Azido-PEG8-CH2CO2-NHS; N3-PEG8-C2-NHS ester; N3-PEG8-CH2CH2COONHS Ester; 1-[(1-Azido-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(27-azido-1-oxo-4,7,10,13,16,19,22,25-octaoxaheptacos-1-yl)oxy]-; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester
IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
InChI	InChI=1S/C23H40N4O12/c24-26-25-4-6-32-8-10-34-12-14-36-16-18-38-20-19-37-17-15-35-13-11-33-9-7-31-5-3-23(30)39-27-21(28)1-2-22(27)29/h1-20H2
InChIKey	AZXJVYAMFTUKFC-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DMSO (10 mm)
Related CAS	1108750-59-9 (polymer)
Appearance	Pale Yellow or Colorless Oily Liquid
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
Storage	Store at 2-8°C

Azido-PEG8-NHS ester, a versatile functional reagent, finds widespread application in bioconjugation and molecular biology. Here are four key applications of Azido-PEG8-NHS ester presented with high perplexity and burstiness:

Bioconjugation: Serving as a cornerstone in bioconjugation, Azido-PEG8-NHS ester acts as a conduit to bind biomolecules such as peptides, proteins, and nucleic acids through the intricate dance of click chemistry reactions. This reagent facilitates precise site-specific labeling and conjugation, preserving the biological activity of the molecules involved. These conjugates play an indispensable role in a myriad of diagnostic and therapeutic technologies, propelling the boundaries of biotechnological advancements.

Protein Labeling: In the realm of proteomics research, Azido-PEG8-NHS ester emerges as a powerful tool in protein labeling, allowing for the attachment of fluorescent dyes, biotin, or other functional groups. This enables the meticulous study of protein localization, interactions, and dynamics within the intricate confines of cells. The PEG spacer confers flexibility and mitigates steric hindrance, ensuring the functionality of the labeled proteins remains unscathed, unraveling the intricate web of protein function and structure with unprecedented detail.

Surface Modification: Azido-PEG8-NHS ester emerges as a game-changer in surface modification, enhancing the usability of nanoparticles, microarrays, and biosensors in the vast landscape of bioscience applications. The azide group forms robust attachments to alkyne-modified surfaces through the intricate interplay of click chemistry, resulting in stable and durable surface modifications. This cutting-edge technique elevates the sensitivity and specificity of diverse detection platforms, paving the way for groundbreaking advancements in biosensing technology.

Drug Delivery Systems: At the forefront of targeted drug delivery systems, Azido-PEG8-NHS ester plays a pivotal role in conjugating therapeutic agents to targeting moieties like antibodies or peptides. This strategic conjugation facilitates precise drug delivery to specific tissues or cells, enhancing the efficacy of therapeutics while simultaneously reducing the dreaded specter of side effects. With this innovative approach, the promise of personalized medicine and enhanced patient outcomes becomes an attainable reality, reshaping the landscape of drug delivery with unparalleled precision and efficacy.

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