Azido-PEG1-NHS ester

Name: Azido-PEG1-NHS ester
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1807530-06-8

Cat No.: BPG-0868

Purity: ≥95%

4.5

Azido-PEG1-NHS ester is a PEG derivative containing an azide group and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, and DBCO via Click Chemistry to yield a stable triazole linkage. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

Category	Azido-PEGn-NHS ester
Molecular Formula	C9H12N4O5
Molecular Weight	256.22
Appearance	Pale Yellow Oily Liquid
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Store at 2-8°C

Structure of 1807530-06-8

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Specification
Key Product Attributes
Reaction & Conjugation Properties

Synonyms	N3-PEG1-CH2CH2COONHS; Propanoic acid, 3-(2-azidoethoxy)-, 2,5-dioxo-1-pyrrolidinyl ester; 1-{[3-(2-Azidoethoxy)propanoyl]oxy}-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[3-(2-azidoethoxy)-1-oxopropoxy]-
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-(2-azidoethoxy)propanoate
CanonicalSMILES	C1CC(=O)N(C1=O)OC(=O)CCOCCN=[N+]=[N-]
InChI	InChI=1S/C9H12N4O5/c10-12-11-4-6-17-5-3-9(16)18-13-7(14)1-2-8(13)15/h1-6H2
InChIKey	MGKGKSFTIINDPY-UHFFFAOYSA-N
Purity	≥95%
Solubility	Soluble in DCM, DMF, DMSO
RelatedCAS	1108750-59-9 (polymer)

PEGType	Discrete PEG Linker
PEGArchitecture	Linear
Functionality	Heterobifunctional

ReactiveToward	Terminal Alkynes; Strained Alkynes (DBCO/BCN); Primary Amines
ReactionChemistry	CuAAC Click Chemistry; SPAAC Click Chemistry; Activated-Ester Amine Coupling
BiomoleculeCompatibility	Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides
ResearchUse	Copper-Free Azide–Cyclooctyne Ligation; Copper-Catalyzed Azide–Alkyne Ligation; Amine-Selective Biomolecule Coupling