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NHS-PEG4-azide

CAS No. CAS No.: 944251-24-5
Cat No. Cat No.: BPG-3557
Purity Purity: 95%
HNMR HNMR
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NHS-PEG4-azide is a PEG-containing bioorthogonal conjugation building block that provides an azide handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is azide bioorthogonal handle; requires complementary click handle on the antibody. The structure includes peg4 spacer to provide hydrophilic spacing. Conjugation can be performed using spaac with dbco/bcn-functionalized partner or cuaac with terminal alkyne partner, depending the complementary handle. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.

Category Azido-PEGn-NHS ester
Molecular Formula C15H24N4O8
Molecular Weight 388.37
Appearance Colorless to Slightly Yellow Oily Matter
Shipping Room temperature
Storage Store at -20 °C
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NHS-PEG4-azide

Structure of 944251-24-5

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  • Specification
  • QC Data
Synonyms Azido-PEG4-CH2CO2-NHS; N3-PEG4-C2-NHS ester; N3-PEG4-CH2CH2COONHS Ester; Azido-PEG4-NHS ester; N-Succinimidyl 15-Azido-4,7,10,13-tetraoxapentadecanoate; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate; 1-[(1-Azido-15-oxo-3,6,9,12-tetraoxapentadecan-15-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(15-azido-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)oxy]-
IUPACName (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCN=[N+]=[N-]
InChI InChI=1S/C15H24N4O8/c16-18-17-4-6-24-8-10-26-12-11-25-9-7-23-5-3-15(22)27-19-13(20)1-2-14(19)21/h1-12H2
InChIKey OIGKWPIMJCPGGD-UHFFFAOYSA-N
Purity 95%
Solubility Soluble in Acetonitrile, Dimethyl Sulfoxide
RelatedCAS 1108750-59-9 (polymer)

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