Fmoc-N-amido-PEG1-acid

Name: Fmoc-N-amido-PEG1-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 1654740-73-4

Cat No.: BPG-2016

Purity: >98%

4.5

Fmoc-N-amido-PEG1-acid is a PEG linker containing a Fmoc-protected amine and a terminal carboxylic acid. The Fmoc group can be deprotected under the basic conditions to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Category	Fmoc-N-amido-PEGn-acid
Molecular Formula	C20H21NO5
Molecular Weight	355.38
Appearance	Pale Yellow or Colorless Oily Matter
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Structure of 1654740-73-4

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Specification
Key Product Attributes
Reaction & Conjugation Properties

Synonyms	Fmoc-6-Amino-4-oxahexanoic acid; Fmoc-N-amido-PEG1-acid; Fmoc-NH-PEG1-C2-acid; Fmoc-NH-PEG1-CH2CH2COOH; 6-(Fmoc-amino)-4-oxahexanoic Acid; Fmoc-AEP; Fmoc-PEG1-propionic acid; Propanoic acid, 3-[2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]ethoxy]-; 3-[2-(Fmoc-amino)ethoxy]propanoic acid
IUPACName	3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]propanoic acid
CanonicalSMILES	C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCC(=O)O
InChI	InChI=1S/C20H21NO5/c22-19(23)9-11-25-12-10-21-20(24)26-13-18-16-7-3-1-5-14(16)15-6-2-4-8-17(15)18/h1-8,18H,9-13H2,(H,21,24)(H,22,23)
InChIKey	LHBCOPWWQKLECJ-UHFFFAOYSA-N
BoilingPoint	589.9±40.0 °C at 760 mmHg
Purity	>98%
Density	1.261±0.06 g/cm3 (Predicted)
Solubility	Soluble in DMSO
RelatedCAS	850312-72-0 (polymer)
ExactMass	355.14197277
LogP	3.40730
Pictogram	Irritant
Signal	Warning
PrecautionaryStatementCodes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

PEGType	Discrete PEG Linker
PEGArchitecture	Linear
Functionality	Monofunctional (Reactive)
ProtectingGroup	Fmoc

ReactiveToward	Primary Amines (after activation)
ReactionChemistry	Carbodiimide-Mediated Amide Coupling (EDC/NHS)
BiomoleculeCompatibility	Proteins / Antibodies; Peptides; Amine-Modified Oligonucleotides
ResearchUse	Carboxyl-to-Amine Coupling after Activation; Amide Bond Formation