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AcS-PEG1-acid

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Category	AcS-PEGn-acid
Catalog NO.	BPG-1069
Product Name	AcS-PEG1-acid
CAS	2093977-01-4
Molecular Formula	C7H12O4S
Molecular Weight	192.23

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Description	AcS-PEG1-acid is a PEG linker containing a sulfur acetyl group and a terminal carboxylic acid. The sulfur acetyl group can be deprotected to produce a thiol moiety. The terminal carboxylic acid can react with primary amines in the presence of EDC or HATU to produce amide bonds. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
Synonyms	S-acetyl-PEG1-acid; S-acetyl-PEG1-COOH; S-Acetyl-PEG1-C2-acid; 3-(2-(acetylthio)ethoxy)propanoic acid
IUPAC Name	3-(2-acetylsulfanylethoxy)propanoic acid
Canonical SMILES	O=C(O)CCOCCSC(C)=O
InChI	InChI=1S/C7H12O4S/c1-6(8)12-5-4-11-3-2-7(9)10/h2-5H2,1H3,(H,9,10)
InChIKey	HSNPMMDQAHUVKG-UHFFFAOYSA-N
Purity	≥95%
Related CAS	956497-30-6 (polymer)
Appearance	Pale Yellow or Colorless Oily Matter
Storage	Store at 2-8°C

AcS-PEG1-acid, a polyethylene glycol (PEG) derivative with diverse applications in biochemistry and biotechnology, unveils its versatility through four key applications rich in perplexity and burstiness:

Drug Delivery: Embarking on a dynamic journey, AcS-PEG1-acid intricately conjugates with therapeutic molecules, enhancing their solubility, stability, and half-life in the bloodstream. This complex PEGylation process optimizes drug pharmacokinetics, enhancing efficacy in disease treatment. By reducing immunogenicity and increasing bioavailability, it sets the stage for advanced drug delivery systems.

Bioconjugation: A central player in bioconjugation strategies, AcS-PEG1-acid elegantly facilitates the linking of proteins, peptides, and bioactive molecules. The PEG moiety acts as a flexible spacer, alleviating steric hindrance and enhancing molecule flexibility. This critical application shapes cutting-edge biomaterials and biosensors, driving the development of innovative diagnostic and therapeutic agents.

Surface Modification: Unveiling its transformative potential, AcS-PEG1-acid emerges as a foundational element in surface modification techniques, creating biocompatible and non-fouling surfaces on various medical devices and implants. Through strategic PEG coating, it shields against protein adsorption and cellular adhesion, reducing the risk of biofilm formation and infection. This innovative approach enhances the effectiveness and durability of medical devices and implants in clinical settings.

Theranostics: Crossing into the realm of therapeutics and diagnostics, AcS-PEG1-acid plays a pivotal role in revolutionizing theranostic applications, seamlessly integrating therapeutic and diagnostic functionalities into a unified platform. Through intricate conjugation with imaging agents and therapeutic compounds, multifunctional nanoparticles are created, enabling simultaneous disease diagnosis and treatment. This innovative approach enhances the precision and efficacy of personalized medicine strategies.

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