Multi-Arm PEG

2-Arm PEG ¹¹
4-Arm PEG ⁵⁴
6-Arm PEG ²
8-Arm PEG ⁴⁴

Catalog No.	Name	M.W.	Purity
In stock BPG-4833	Amino-Tri-(Propargyl-PEG2-ethoxymethyl)-methane TFA Salt	712.84	98%
In stock BPG-4832	Amino-Tri-(Azide-PEG4-ethoxymethyl)-methane	1070.20	98%
In stock BPG-2703	3-Arm PEG-NH2 (glycerol), MW 15k-20k	Customizable	N/A

Background

Polyethylene glycol (PEG) is a versatile polymer that has found numerous applications in various fields, including drug delivery, biotechnology, and materials science. One of the most promising forms of PEG is multi-arm PEG, which is a branched polymer with multiple arms. Multi-arm PEG is an excellent candidate for various applications due to its unique characteristics, such as high water solubility, biocompatibility, and low toxicity. BOC Sciences is a leading supplier of multi-armed PEG and other PEG derivatives. We offer a wide range of multi-armed PEG products with different molecular weights, arm lengths and functional groups. Our multi-arm-PEG products include a variety of functionalized and structured 2-Arm PEGs, 3-Arm PEGs, 4-Arm PEGs, 6-Arm PEGs and 8-Arm PEGs.

Fig. 1. Examples of applications of 4-arm PEG (Frontiers in Bioengineering and Biotechnology. 2019, 7: 410).

Applications of Multi-Arm PEG

Multi-armed PEGs have been widely used in various fields such as drug delivery, tissue engineering, and diagnostic imaging.

Applications of Multi-Arm PEG

Multi-arm PEG in Drug Delivery

Multi-arm PEGs are used to improve the pharmacokinetics and biodistribution of drugs. Multi-armed PEG can be used as a coating material for nanoparticles and liposomes to enhance drug stability and circulation time in the bloodstream. In addition, multi-arm PEG can also be used as a linker to couple drugs to antibodies or polypeptides to improve the specificity and efficacy of drugs.

Multi-arm PEG in Tissue Engineering

Multi-armed PEGs can be used to create hydrogels that mimic tissue extracellular matrix (ECM), which can be used as scaffolds for cell growth and tissue regeneration. In addition, the multi-arm PEG hydrogel can be used as a drug delivery vehicle for growth factors and cytokines, which can promote tissue regeneration and repair.

Multi-Arm PEG in Diagnostic Imaging

Multi-arm PEG can be used to create contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) scans. For example, multi-armed PEG can be used as a coating material for nanoparticles, which can enhance the contrast of images. In addition, multi-arm PEG can also be used as a linker to couple imaging agents to antibodies or peptides, thereby improving the specificity and sensitivity of imaging.

Features of Multi-Arm PEG

Multi-arm PEG is highly water soluble which makes it easy to handle and process.
Multi-arm PEGs are biocompatible and non-toxic, making them safe for use in biological systems.
The high molecular weight nature of multi-arm PEG makes it less prone to degradation and increases its stability in the bloodstream.
A multi-arm PEG has multiple arms, which increases its surface area and allows multiple sites for functionalization.

Custom Synthesis Services of Multi-Arm PEG

BOC Sciences also provides custom synthesis services for multi-armed PEGs and other PEG derivatives. We have a team of experienced chemists and state-of-the-art facilities to produce multi-armed PEGs of high purity and quality. BOC Sciences is committed to providing quality products and services to customers in the polyethylene glycol field.

Our PEG cGMP Manufacturing Advantages

BOC Sciences also provides low to high volume cGMP manufacturing of PEG. Our PEG cGMP manufacturing always ensures high purity and quality of the final product. Our cGMP manufacturing process strictly adheres to regulatory guidelines, which ensures that the final product meets all necessary safety and quality standards. We allow full traceability of products from raw material to finished product. Contact us to learn more about our products and services.

Reference

Sheth, S. et al. Predicting Drug Release From Degradable Hydrogels Using Fluorescence Correlation Spectroscopy and Mathematical Modeling. Frontiers in Bioengineering and Biotechnology. 2019, 7: 410.

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