PEGylation of DNA
BOC Sciences has been an industry leader in bioconjugation technology. We have created a complete PEGylation platform, which can realize preclinical research from the production and supply of upstream raw materials to PEGylated DNA design, synthesis, chemical modification, and delivery system development. We are world-renowned for unrivaled quality and exceptional success rates.
Benefits of DNA PEGylation
Gene therapy is to introduce DNA into cells as a drug, corrects the effects of mutated genes in the body, and directly and precisely repairs gene mutations, thereby treating diseases. Successful gene therapy depends largely on delivering nucleic acid molecules into cells. However, the safe and effective delivery of therapeutic plasmid deoxyribonucleic acid (pDNA) to cells is one of the major obstacles to the clinical success of gene therapy due to the lack of safe and effective gene delivery vehicles. When polyethylene glycol is coupled to the surface of DNA molecules, it can change the solubility of DNA molecules, form a space barrier, and reduce enzymatic hydrolysis. In addition, PEGylated DNA also has the advantages of attenuating toxicity, reducing immunogenicity, prolonging half-life, changing tissue distribution, and increasing the concentration of target sites, which is the mainstream solution for long-acting drugs.
Solutions of DNA PEGylation
Our PEGylation services of DNA can be highly customized to meet your individual needs and are supported by our dedicated experts and global presence.
Project | Content |
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Preparation of DNA | Including cultivation and amplification, bacterial lysis, DNA purification and other steps. |
Preparation of functionalized PEGs | Mainly through multiple steps such as terminal carboxylation, acyl chloride, esterification with polyols, and hydrolysis, different relative molecular weights, terminal functional groups, and block, graft, hyperbranched, or star-shaped PEGs can be obtained. |
Preparation of PEGylated DNA |
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Analysis of PEGylated DNA | These include determining the turbidity of DNA solutions, verifying complex formation using NMR spectroscopy, analyzing the conformational properties of DNA-PEG complexes, studying the structure of DNA-PEG complexes in ultrapure water, studying the stability of PEG-grafted DNA, and more. |
Core Equipment
- Agarose gel and electrophoresis apparatus
- Centrifuge
- Dialysis equipment
- Lyophilizer
- Micropipettor
- Transmission electron microscope
- Spectrophotometer
- HPLC, GC, IR, GPC
- Vortex mixer
- Automatic polarimeter
- Constant humidity titrator
- Mass spectrometer
Advantages of PEGylation
- Broadens the range of functional DNA systems
- Protecting DNA in biopharmaceutical environments
- Accelerating realization of metal-free catalysis
- Improve DNA transfection efficiency
Our wide selection of PEGs, and modified methods based on years of research and development experience, provide almost unlimited possibilities for the development of PEGylated DNA products. We can perform synthesis at any scale and level of purity you require, no matter the difficulty. When you partner with BOC Sciences, you minimize the risk of PEGylation failure, ensuring a more worry-free ordering experience and a more efficient delivery process.
In order to provide you with accurate and efficient services, please contact us first and explain your needs, and we will provide you with a quotation as soon as possible.
Why BOC Sciences?
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Large Stock
More than 2000+ products in inventory
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Global Delivery
Warehouses in multiple cities to ensure fast delivery
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mg to kg
Multi specification for academic research and industrial production
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24/7 Technical Support
Strict process parameter control to ensure product quality
Technical Support
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Ultrafiltration Technique
Products
- Lipids
- PEG Derivatives by Structure
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PEG Derivatives by Functional Group
- Acrylate/Acrylamide/Methacrylate PEG
- Aldehyde (Ald/CHO)PEG
- Alkyne PEG
- Amino PEG, PEG amine(-NH2)
- Azide PEG, Azido PEG(-N3)
- Biotin PEG
- Boc/Fmoc protected amine PEG
- Carboxylic Acid(-COOH) PEG
- Cholesterol PEG
- DBCO PEG
- DSPE PEG
- Epoxide glycidyl ether PEG
- FITC PEG
- Halide (chloride, bromide) PEG
- Hydrazide PEG
- Hydroxyl(-OH) PEG
- Maleimide(-MAL) PEG
- Multi-Arm PEG
- NHS ester PEG
- Nitrophenyl carbonate (NPC) PEG
- Norbornene PEG
- Olefin/Alkene/Vinyl PEG
- Orthopyridyl disulfide (OPSS) PEG
- Phosphate PEG
- Rhodamine PEG
- SCM PEG
- Silane PEG
- Sulfonate (tosyl, mesyl, tresyl) PEG
- tert-Butyl protected carboxylate PEG
- Thiol(-SH) PEG
- Vinylsulfone PEG
- PEG Copolymers
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PEG Raw Materials
- Small-molecule Polyethylene Glycol
- Polyethylene Glycol 1000
- Polyethylene Glycol 10000
- Polyethylene Glycol 1500
- Polyethylene Glycol 200
- Polyethylene Glycol 2000
- Polyethylene Glycol 20000
- Polyethylene Glycol 400
- Polyethylene Glycol 4000
- Polyethylene Glycol 600
- Polyethylene Glycol 6000
- Polyethylene Glycol 800
- Polyethylene Glycol 8000
Services
- PEGylation Services
- PEGylation Analysis and Method Verification
- Surface Modification and Functionalization
- PEGylated Biodegradable Polymers Synthesis
- Monodisperse PEG Synthesis
- Custom Synthesis PEG Derivatives
- PEG cGMP Manufacture
- PEG Crosslinking Services
Resources
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Technical Information
- Aqueous Two-Phase System (ATPS) Technique
- Capillary Electrophoresis (CE) Technique
- Enzyme-linked immunosorbent assay (ELISA) Technique
- High performance liquid chromatography (HPLC) Technique
- Hydrophobic Interaction Chromatography (HIC) Technique
- Introduction of Polyethylene Glycol (PEG)
- Ion Exchange Chromatography (IEX) Technique
- PEG for Chemical Synthesis
- PEG for Cosmetic Application
- PEG for Drug Delivery
- PEG for Imaging Diagnosis
- PEG for Pharmaceutical Preparation
- PEG for Tissue Engineering
- PEGylated Protein Purification Techniques
- Radiolabeling Technique
- SDS-PAGE Technique
- Size Exclusion Chromatography (SEC) Technique
- Ultrafiltration Technique
- Industry News
Our Feature
BOC Sciences supplies a unique variety of PEG derivatives and functional PEG polymers. Our products offer the most diverse collection of reactivity, ready-to-use functionality, and molecular weight options that you will not find anywhere else.

PEGylation of Peptides
and Proteins
Reduce the Immunogenicity of Peptide/Protein Drugs
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APPLICATIONS

PEG linkers For Drug
Improved Circulation Half-Life
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