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Dodecaethylene glycol

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Category Small-molecule Polyethylene Glycol
Catalog NO. BPG-2330
Product Name Dodecaethylene glycol
CAS 6790-09-6
Molecular Formula C24H50O13
Molecular Weight 546.65
Dodecaethylene glycol
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Description Dodecaethylene glycol is a polyethylene glycol (PEG)-based PROTAC linker that can be used in the synthesis of a series of PROTACs.
Synonyms HO-PEG12-OH; 3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diol; Dodecaethyleneglycol
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O
InChI InChI=1S/C24H50O13/c25-1-3-27-5-7-29-9-11-31-13-15-33-17-19-35-21-23-37-24-22-36-20-18-34-16-14-32-12-10-30-8-6-28-4-2-26/h25-26H,1-24H2
InChIKey WRZXKWFJEFFURH-UHFFFAOYSA-N
Boiling Point 325°C at 5 mmHg
Melting Point 38°C
Purity ≥95%
Density 1.116 g/cm3
Solubility Soluble in DMSO
Appearance Pale Yellow or Colorless Liquid
Application HO-PEG12-OH (CAS# 6790-09-6) is a useful research chemical compound.
Storage Store at 2-8°C
Exact Mass 546.32514165
LogP -0.84640

Dodecaethylene glycol, a versatile compound with diverse applications across scientific domains, finds itself at the forefront of innovation. Here are four key applications of dodecaethylene glycol presented with a high degree of perplexity and burstiness:

Pharmaceutical Formulations: Acting as a solubilizing agent and stabilizer in pharmaceutical formulations, dodecaethylene glycol plays a pivotal role in enhancing the bioavailability and therapeutic efficacy of poorly water-soluble drugs. Not only does it aid in dissolving these drugs, but it also safeguards the active pharmaceutical ingredients from degradation over time, ensuring their potency remains intact.

Biochemical Research: Within the intricate landscape of biochemical research, dodecaethylene glycol emerges as a versatile reagent and solvent utilized in various analytical assays. Its exceptional properties, including low toxicity and high solubility, render it indispensable for tasks such as protein purification and enzyme assays. Researchers rely on its stability-preserving qualities to maintain the integrity and activity of biomolecules throughout their experiments.

Polymer Chemistry: Serving as a fundamental building block in the synthesis of polyether and polyurethane polymers, dodecaethylene glycol contributes significantly to the production of versatile materials. These polymers find applications in creating flexible foams, adhesives, and coatings that exhibit heightened chemical resistance and durability. The unique characteristics of dodecaethylene glycol play a crucial role in enhancing the overall performance and utility of these advanced polymers.

Biomedical Engineering: At the intersection of biology and engineering, dodecaethylene glycol takes center stage in the realm of biomedical engineering. Its application in modifying surfaces and developing biocompatible materials facilitates the grafting of medical devices and implants with improved compatibility for biological tissues. This innovative approach not only mitigates the risks of adverse immune reactions but also enhances the functionality of medical implants, showcasing the potential of dodecaethylene glycol in revolutionizing biomedical technologies.

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