4A-MPLA

Name: 4A-MPLA
Brand: BOC Sciences
Rating: 5 (1 reviews)

CAS No.: 2260669-09-6

Cat No.: BPG-3017

Purity: 98%

4.5

4A-MPLA, the synthetic antigen-adjuvant, is employed in vaccines that bolster immune responses to infectious agents and cancers. The toll-like receptor 4 (TLR4) is vigorously activated by this powerful agonist, which, when given with other adjuvants, augments vaccine effectiveness during vaccination programs intended to combat bacterial and viral infections, including tuberculosis, influenza, and meningitis.

Category	Adjuvants
Molecular Formula	C68H132N3O19P
Molecular Weight	1326.76
Appearance	White Powder
Storage	Store at -20 °C

Structure of 2260669-09-6

Ordering Information

*For research and manufacturing use only. We do not sell to patients.

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cGMP Capacity

cGMP-grade lipid manufacturing
Scalable from milligrams to kilograms
20+ years expertise in lipid chemistry
In-stock supply in the US and Europe
Comprehensive QC testing with COA, MSD
High-purity synthetic and natural lipids
Covers phospholipids, sterols, and sphingolipids
100+ types of custom lipid modifications
Specialized lipids for LNP delivery
Functionalized and fluorescently labeled lipids

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Specification

Synonyms	Monophosphoryl Tetra-acyl Lipid A; α-D-Glucopyranose, 2-deoxy-6-O-[2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-, 3-[(3R)-3-hydroxytetradecanoate], ammonium salt (1:1)
IUPACName	azanium;[(2R,3S,4R,5R,6R)-6-[[(2R,3S,4R,5R,6S)-3,6-dihydroxy-5-[[(3R)-3-hydroxytetradecanoyl]amino]-4-[(3R)-3-hydroxytetradecanoyl]oxyoxan-2-yl]methoxy]-4-hydroxy-2-(hydroxymethyl)-5-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]oxan-3-yl] hydrogen phosphate
CanonicalSMILES	CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O)NC(=O)C[C@@H](CCCCCCCCCCC)O)OC(=O)C[C@@H](CCCCCCCCCCC)O)O)CO)OP(=O)(O)[O-])O.[NH4+]
InChI	InChI=1S/C68H129N2O19P.H3N/c1-5-9-13-17-21-25-26-30-34-38-42-46-59(76)85-54(45-41-37-33-29-24-20-16-12-8-4)49-58(75)69-61-64(79)65(89-90(81,82)83)55(50-71)87-68(61)84-51-56-63(78)66(88-60(77)48-53(73)44-40-36-32-28-23-19-15-11-7-3)62(67(80)86-56)70-57(74)47-52(72)43-39-35-31-27-22-18-14-10-6-2;/h52-56,61-68,71-73,78-80H,5-51H2,1-4H3,(H,69,75)(H,70,74)(H2,81,82,83);1H3/t52-,53-,54-,55-,56-,61-,62-,63-,64-,65-,66-,67+,68-;/m1./s1
InChIKey	KREAPURBNFKEHO-BNSRHSNQSA-N
Purity	98%
Solubility	Soluble in Chloroform, Methanol, Water
RelatedCAS	2260669-08-5 (free acid)
ShelfLife	1 Year
Hygroscopic	No
LightSensitive	No