BCN-PEG4-NHS ester

Name: BCN-PEG4-NHS ester
Brand: BOC Sciences
Price: 629 USD
Availability: MadeToOrder

CAS No.: 1702356-19-1

Cat No.: BPG-2317

Purity: ≥98%

4.5

BCN-PEG4-NHS ester is a PEG-containing bioorthogonal conjugation building block that provides a BCN strained-alkyne handle for modular click-chemistry workflows. The molecule can be used to introduce a click-reactive group onto an antibody, peptide, linker intermediate, or payload-containing component, depending on the chemistry of its second terminal functionality. Its additional reactive group is nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines. The structure includes peg4 spacer to provide hydrophilic spacing. Conjugation can be performed using spaac with an azide-functionalized antibody or payload; use the second terminal group for orthogonal coupling. The sequence and orientation of the coupling steps should be selected according to the functional groups carried by the two conjugation partners.

Category	Small-molecule Heterobifunctional PEG
Molecular Formula	C26H38N2O10
Molecular Weight	538.59
Appearance	Soild powder
Shipping	Room temperature
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.

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Structure of 1702356-19-1

Ordering Information

*For research and manufacturing use only. We do not sell to patients.

Catalog Number	Name	Size / Price	Stock	Quantity
BPG-2317	BCN-PEG4-NHS ester		In stock

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Specification

Synonyms	BCN-endo-PEG4-NHS; BCN-endo-PEG4-SPA; BCN-exo-PEG4-NHS; rel-2,5-Dioxopyrrolidin-1-yl 1-((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-yl)-3-oxo-2,7,10,13,16-pentaoxa-4-azanonadecan-19-oate
IUPACName	(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[[(1S,8R)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CanonicalSMILES	C1CC2C(C2COC(=O)NCCOCCOCCOCCOCCC(=O)ON3C(=O)CCC3=O)CCC#C1
InChI	InChI=1S/C26H38N2O10/c29-23-7-8-24(30)28(23)38-25(31)9-11-33-13-15-35-17-18-36-16-14-34-12-10-27-26(32)37-19-22-20-5-3-1-2-4-6-21(20)22/h20-22H,3-19H2,(H,27,32)/t20-,21+,22?
InChIKey	MFQCOKMBYCIQEJ-CBQGHPETSA-N
Purity	≥98%
Density	1.28±0.1 g/cm3