-20°C for long-term preservation, keep in dry and avoid sunlight. Avoid repeated freezing and thawing.
Soluble in water, DMSO and DMF. Freshly prepared before use.
The 4-arm PEG derivative belongs to a branched PEG. It has larger molecular weight due to increased number of active terminal groups, therefore it can carry more drug molecules. Multi-arm PEG derivatives are commonly used in drug delivery systems. The molecular weight of the modified drug is increased that is not easily eliminated by metabolism in the body. In addition, the dispersity and solubility of the modified drug in the body will be improved. Multi-arm PEG derivatives can also modify the surface of biological materials or form new biomedical materials.
1. Fechler N, Badi N, Schade K, et al. Thermogelation of PEG-based macromolecules of controlled architecture. Macromolecules, 2008, 42(1): 33-36. 2. T, Pan H, et al. Synthesis and characterization of enzymatically degradable PEG-based peptide-containing hydrogels.Macromolecular bioscience, 2010, 10(4): 445-454.