DOPE

Name: DOPE
Brand: BOC Sciences
Price: 439 USD
Availability: MadeToOrder

CAS No.: 4004-05-1

Cat No.: BPG-3885

Purity: ≥95%

4.5

DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) is a zwitterionic phospholipid with two unsaturated oleoyl chains, imparting high fusogenicity and a tendency to form non-lamellar structures under certain conditions. These characteristics make DOPE particularly valuable in liposome formulations designed for cargo release, as it promotes membrane destabilization and fusion in response to environmental triggers. It is extensively used in gene delivery and as a helper lipid in nanoparticle systems where efficient endosomal escape is required.

Category	Phospholipid
Molecular Formula	C41H78NO8P
Molecular Weight	744.05
Appearance	White to light yellow to light orange freeze-dried powder
Shipping	Ambient temperature
Storage	Store at -20 °C

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Structure of 4004-05-1

Ordering Information

*For research and manufacturing use only. We do not sell to patients.

Catalog Number	Name	Size / Price	Stock	Quantity
BPG-3885	DOPE		In stock

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Specification
QC Data

Synonyms	18:1 PE; 1,2-Dioleoyl-sn-glycero-3-PE; 1,2-Dioleoyl-sn-glycero-3-Phosphoethanolamine; 1,2-DOPE; PE(18:1/18:1); Phophatidylethanolamine(18:1n9/18:1n9); Phophatidylethanolamine(18:1w9/18:1w9); 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; PE(18:1(9Z)/18:1(9Z)); 2-Aminoethyl (R)-2,3-Bis(oleoyloxy)propyl Hydrogen Phosphate; Olein, 1,2-di-, 2-aminoethyl hydrogen phosphate, L-; 9-Octadecenoic acid (9Z)-, (1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester
IUPACName	[(2R)-3-[2-aminoethoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
CanonicalSMILES	CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)OCCN)OC(=O)CCCCCCCC=CCCCCCCCC
InChI	InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1
InChIKey	MWRBNPKJOOWZPW-NYVOMTAGSA-N
BoilingPoint	759.2±70.0 °C at 760 mmHg
MeltingPoint	200 °C
Purity	≥95%
Density	1.008±0.06 g/cm3 (Predicted)
Solubility	Soluble in Chloroform, DMSO
ShelfLife	≥2 years