| Category | Small-molecule Heterobifunctional PEG |
| Molecular Formula | C₉H₁₇NO₃ |
| Molecular Weight | 187.24 |
| Appearance | Colorless Liquid |
| Shipping | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Propargyl-PEG3-amine
4.5
Propargyl-PEG3-amine is a polyethylene glycol (PEG)-based PROTAC linker. Propargyl-PEG3-amine can be used in the synthesis of a series of PROTACs.
Structure of 932741-19-0
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- Specification
- Key Product Attributes
- Reaction & Conjugation Properties
| Synonyms | Alkyne-PEG3-amine;HC≡C-CH2-PEG3-NH2; Propyne-PEG3-NH2 |
| IUPACName | 2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethanamine |
| CanonicalSMILES | C#CCOCCOCCOCCN |
| InChI | InChI=1S/C9H17NO3/c1-2-4-11-6-8-13-9-7-12-5-3-10/h1H,3-10H2 |
| InChIKey | MREICTHRFCQNJR-UHFFFAOYSA-N |
| BoilingPoint | 267.4±25.0 °C at 760 mmHg |
| Purity | >97% |
| Density | 1.0±0.1 g/cm3 |
| Solubility | Water, DMSO, DCM, DMF |
| Pictogram | Corrosive, Irritant |
| Signal | Danger |
| PrecautionaryStatementCodes | P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P319, P321, P330, P363, P403+P233, P405, and P501 |
| PEGType | Discrete PEG Linker |
| PEGArchitecture | Linear |
| Functionality | Heterobifunctional |
| ReactiveToward | Azides; Activated Carboxyls / Activated Esters |
| ReactionChemistry | CuAAC Click Chemistry; Amide Coupling |
| BiomoleculeCompatibility | Click-Handle-Modified Proteins / Peptides; Click-Handle-Modified Antibodies; Click-Handle-Modified Oligonucleotides; Small Molecules / Probes; Proteins / Antibodies; Peptides; Carboxyl-Modified Oligonucleotides |
| ResearchUse | Copper-Catalyzed Azide–Alkyne Ligation; Amide Bond Formation |
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